©2004 Nature Publishing Group H.-G. Rammensee, Nature, 427:203–4, Jan. 15, 2004.
Initial models of protein splicing (as shown at left) had protein cleavage and ligation occurring through unidentified processes, with further truncation occurring in the proteasome. Further evidence suggests that the proteasome actually mediates both hydrolysis and reformation of amide bonds (as shown at right) and that remaining N-terminal amino acids are removed in the cytosol or endoplasmic reticulum.
James Yang, a surgeon working at the National Cancer Institute in Bethesda, Md., looked despondently at a patient's chest CT scan in 1998. Most of Yang's patients have late stage metastasized renal cancer; few of them survive. By the looks of the scan, this patient was in trouble. Metastasized tumors bloomed throughout his chest.
One spot on the scan caught Yang's eye, though. While most of the lung tumors were growing, one had shrunk noticeably since the last scan. Yang circled ...
