Immunity is the Best Biomarker

Faith in the promise of pharmacogenomics has changed the plan for primary healthcare.

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Courtesy of BD Biosciences

Data summary of a four-color flow cytometric analysis of 40 healthy blood donors (arrayed from left to right). The intensity of the bars represents the frequency of cells (around 0.1% to 10.0%) that responded to classes of stimuli (arrayed from top down). The responses include the production of IFN-γ, IL2, or TNFα among CD4+ or CD8+ T cells. White bars represent missing data and yellow represents <0.1% responders. Responses to CMV peptides (top) cluster among CMV-seropositive donors (left).

Faith in the promise of pharmacogenomics has changed the plan for primary healthcare. We expect, someday, that doctors will discern what medicines to prescribe based in part on the mixture of genes sitting on the paper-covered exam tables in their offices.

But while I'm delighted about personalized medicine and its attendant technical and business innovations, I doubt that pharmacogenomics will drive healthcare much. I liken it to trying ...

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