Editorial

Wanted: Scientific Heroes
Wanted: Scientific Heroes
Who would have thought that a ragtag group of entertainers could have an impact on the biggest social and political questions of the day?

About Us

Meet This Issue's Contributors
Meet This Issue's Contributors
's first assignment as a field applications specialist for Coulter in 1983 was to walk company founder Wallace H. Coulter through a FASEB meeting, translating some of the biology to the renowned electrical engineer who discovered the Coulter principle.

Letter

, the USDA, and the CDC
, the USDA, and the CDC
I am saddened to see the level of oversight of these dangerous experiments at federal institutions.
TB and phenothiazines
TB and phenothiazines
Re: "Turning back the tuberculosis tide."1 My group has published a number of studies and reviews that provide evidence that phenothiazines have activity against all strains of Mycobacterium tuberculosis regardless of their antibiotic susceptibitility status.23 We have shown over the past 15 years that although phenothiazines have in vitro activity against tuberculosis (TB), the concentrations needed are in the order of 20 ug/ml and the maximum concentration that can be achieved in a human is le
The costs of software
The costs of software
Re: "Biology by the Numbers."1 Software licensing is a major factor as to why we do not use MatLab much, or why we do not use some packages, like SAS, at all. We are a 501c(3) non-profit, basic research institute with our own funding, yet many companies like MatLab or SAS will not give us "academic pricing:" because we are not a degree granting institution. Software vendors often refuse to let us share single licenses, and they don't seem to understand they are limiting the availability of their

Opinion

What the Internet says about Science
What the Internet says about Science
The Web has changed the way in which many researchers access scientific information, conduct research, communicate their findings, and share data.

Notebook

Nature
Nature
, you might have been momentarily forgiven for thinking you were reading a celebrity magazine.
The flies are in the mail
The flies are in the mail
had a consignment destined for overseas returned by the US Postal Service (USPS).
Wanna bet on that hypothesis?
Wanna bet on that hypothesis?
In 1980, Stanford biologist Paul Ehrlich took up economist Julian Simon on a bet that the market price of five metals would drop over the next decade.

Feature

The Forecast for Immunology
The Forecast for Immunology
For most, immunity is simply there when you need it, like the umbrella sitting by the door.
Another Kind of Antigen
Another Kind of Antigen
The discovery that lipids can serve as antigens first stunned the immunological community a decade ago.

Hot Paper

The Innate Immunity Adaptor List Grows
The Innate Immunity Adaptor List Grows
Innate immunity, the first line of defense against infection, has revealed surprising complexity for what is considered a relatively primitive and conserved function.

Vision

Immunity is the Best Biomarker
Immunity is the Best Biomarker
Faith in the promise of pharmacogenomics has changed the plan for primary healthcare.

Tools and Technology

Cells in Motion
Cells in Motion
Though we think of them as blood cells, lymphocytes spend much of their time in distinct locations in the body.
And Now, Mosaic Mice
And Now, Mosaic Mice
Mosaic animals, which contain somatic cells with different genotypes, allow researchers to track how mutation or deletion of target genes affects cell development.
Don't Release This Catch!
Don't Release This Catch!
Researchers often use immunoprecipitation (IP) to isolate specific proteins from complex samples or to identify protein-protein interactions.

Research

Plant Neurobiology Sprouts Anew
Plant Neurobiology Sprouts Anew
A meeting this past May ushered in the birth, or perhaps rebirth, of a field of study in which the controversy starts at the very name.

Briefs

Interdisciplinary Research
Interdisciplinary Research
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.H. Aldaz et al., "Insights into microtubule nucleation from the crystal structure of human β-tubulin," Nature, 435:523–7, May 26, 2005.The authors have determined the crystal structure of γ-tubulin bound to GTP-γ S (a non-hydrolyzable GTP analog) at 2.7 Å resolution. γ-tubulin forms part of the γ-tubulin ring complex
Sun-free photosynthesis?
Sun-free photosynthesis?
The ocean floor is a dark place for a photosynthetic bacterium.
Non-stimulatory stimulation
Non-stimulatory stimulation
Healthy immune systems are supposed to ignore self-molecules when looking for foreign invaders.

Technology

Thinking Outside the Icebox on DNA Storage
Thinking Outside the Icebox on DNA Storage
Lab freezers are like mom's attic: cluttered with the property of people long gone.
Precast Gels Ascendant
Precast Gels Ascendant
It is a lament heard in labs everywhere, usually on Friday nights: "I can't go out, I've got to run a gel."

BioBusiness

Of Mice and Money
Of Mice and Money
James C. Foster, CEO of Charles River Laboratories, celebrated the company's five years of public trading by ringing the closing bell at the New York Stock Exchange on June 13.
Building It Up, Biotech Style
Building It Up, Biotech Style
Thomas P. Mathers realized in late 2003 that it was time to pump up Peptimmune's pipeline.
Banking on Stem Cells
Banking on Stem Cells
This spring Korea's Seoul National University announced plans to open a human embryonic stem cell bank.
Venture Capital, with a Twist
Venture Capital, with a Twist
Jamie Heywood, chief executive of the Amyotrophic Lateral Sclerosis Therapy Development Foundation (ALSTDF), founded the nonprofit biotech company in 1999 after his brother was diagnosed with ALS.

Update

UK policy draft mandates open access
UK policy draft mandates open access
Papers arising from work funded by the Research Councils UK (RCUK) should be deposited in an open-access repository "at the earliest opportunity, wherever possible at or around the time of publication, in accordance with copyright and licensing arrangements," according to a draft policy that RCUK made public in July.
EU science budget talks falter
EU science budget talks falter
European Union leaders failed to reach an agreement over the EU budget in late June, but Janez Potocnik, European Commissioner for Research, says it doesn't have to be a setback for research in the region.

Closing Bell

Stand (Swim, Wriggle, Crawl, or Fly) and Be Counted
Stand (Swim, Wriggle, Crawl, or Fly) and Be Counted
The scientists were already massing when I arrived at Bronx River Forest on a steamy June morning.