Researchers have uncovered a mechanism whereby macrophages employ their energy-generating organelles to aid in bacterial killing.
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When a macrophage engulfs a bacterium, it triggers a stress pathway in the endoplasmic reticulum (1). This in turn stimulates mitochondria to produce reactive oxygen species (2), which are packaged into vesicles and shuttled to the phagosome (3). There, the damaging molecules are thought to aid in killing the pathogen. Finally, the bacterial remains are degraded once the phagosome fuses with a lysosome (4).
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After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.
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The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.
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