Infographic: What a Trip

Researchers took a mind-bending trip to understand the connections between psychedelic compounds produced by fungi, plants, and humans.

Written byIris Kulbatski, PhD
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Humans have consumed hallucinogenic fungi and plants for thousands of years. Many of these compounds share a common chemical structure with one another and with neurotransmitters widely produced by the human body, such as serotonin. Classic examples are psilocybin, which is synthesized by certain species of fungi, and N,N-Dimethyltryptamine (DMT), which is produced by some plants. The basic chemical structure of DMT is embedded in other psychedelics, including psilocybin.

Chemical structures of DMT, Psilocybin, Serotonin
MODIFIED FROM © ISTOCK.COM, Olesia Lapshina, Eva Almqvist, bestdesigns, Shaiith, designed by Erin Lemieux

The human body also produces DMT. Endogenous psychedelics may perform the following physiological roles:

  • Protect the brain from hypoxic injury
  • Act as neurotransmitters
  • Play a role in an endogenous antidepression system, much like the endogenous opioid system acts against pain

Brain and mushroom illustration
MODIFIED FROM © ISTOCK.COM, Eva Almqvist, bestdesigns, designed by Erin Lemieux
Glowing mushroom on bark
MODIFIED FROM © ISTOCK.COM, bestdesigns, Shaiith, designed by Erin Lemieux

Fungi serve as the digestive and nervous systems
of the forest floor. Their sprawling subterranean mycelia decompose organic detritus into usable nutrients. Mycelia also communicate with soil microorganisms and the root systems of plants and trees. They sense and integrate information using electrical signals and some of the same neurotransmitters as in the human brain and gut.


Read the full story.

Related Topics

Meet the Author

  • Iris Kulbatski, PhD

    Iris, a neuroscientist by training and word surgeon by trade, is an associate science editor with The Scientist's Creative Services Team. Her work has appeared in various online and print publications, including Discover Magazine, Medgadget, National Post, The Toronto Star and others. She holds a PhD in Medical Science and a Certificate in Creative Writing from the University of Toronto. Her left and right brain converse on a regular basis. Once in a while, they collaborate.

    View Full Profile

Published In

<em>The Scientist </em>Fall 2023 cover
Fall 2023

Defying Dogma

To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.

Share
You might also be interested in...
Loading Next Article...
You might also be interested in...
Loading Next Article...
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies