Single-cell technologies reveals subpopulations of microglia that play distinct roles in diseased and healthy brains.

Researchers who spoke with Spectrum say that while brain imaging tools have their limitations, they still hold promise in helping to unlock the brain’s secrets. 

Bryan Black and Lucas Thal will discuss their experiences screening hiPSC-derived neural cells to understand chronic pain and neuroinflammation.

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.

The experimental system, developed and tested in just one patient so far, relies on brain signals associated with handwriting to achieve the fastest communication yet seen with BCI.

Researchers identify new motor neuron subgroups and gain insights into amyotrophic lateral sclerosis (ALS).

Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.

The National Academies’ report touches on ethical issues raised by new technologies such as brain organoids and human-animal chimeras, and suggests that current regulatory oversight is sufficient.

Richard Smith will discuss the importance of ionic flux in in utero neuronal development.

From a loss of taste to dementia, infectious agents cause an array of neurological symptoms.

Impressions that ancient brains left in fossilized skulls reveal that the first human ancestors to migrate out of Africa had much more primitive brains than previously thought.

Researchers find that the animals can account for others’ behavior and circumstances in their strategies.

Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.

Neural connections in the mouse neocortex can release multiple packages of neurotransmitters per electrical impulse, a study finds.

Synapses in the mouse neocortex can release multiple packages of neurotransmitters, suggesting that connection strength is more flexible than previously thought.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.

Two out of three people who received noninvasive ultrasound appear to have gained some level of consciousness, according to preliminary trial results.