<em>The Scientist </em>Fall 2023 cover

Fall 2023

Defying Dogma

To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.

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Features

3D multicolored conceptual image representing hallucinogens and the human brain.

Natural High: Endogenous Psychedelics in the Gut and Brain

Image of someone scratching their skin.

A Chronic Itch: Burrowing Beneath the Skin

A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.

Defying Dogma: Decentralized Translation in Neurons

Illustration of talking AI

What Can ChatGPT-like Language Models Tell Us About the Brain?

Foundations

Illustration showing origami tardigrade, fungi and bacteria.

Magnifying Curiosity with a Pocket Microscope

A man sitting at a desk in a white lab coat holds up a large model of a <em >Drosophila</em> fly. In the background is a window and a bookcase.

The Origins and Recent Promise of Nonsense Suppressor tRNAs

The image shows six different panels containing cells. On each panel, the cells are labelled using a different fluorescent dye that highlights features of a specific organelle within the cells.

Cell Painting: Exploring the Richness of Biological Images

Infographics

Chemical structures of DMT, Psilocybin and serotonin

Infographic: What a Trip

TK

Infographic: Beyond the Nucleus: mRNA Localization in Neurons

The prime editing machinery comprises a prime editing guide RNA (pegRNA) and a Cas9 nickase enzyme fused to a reverse transcriptase.

Infographic: How Prime Editing Works

Infographic showing the selective strengthening of synapses that received stimulation.

Infographic: Synaptic Plasticity in the Sea Slug

Illustration showing how iGluSnFR3, tracks glutamate release at the synapse level. Upon binding to glutamate, the reporter changes its conformation, intensifying the signal of its fluorescent protein.

Infographic: How a Glutamate Sensor Tracks Synapses

Infographic detailing two volume electron microscopy modalities.

Infographic: Drivers of the Expansion of Volume Electron Microscopy

Speaking of Science

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What’s the Transmission?

Profiles

Matthew Disney

A Quest to Drug RNA

Erkin Kuru (left) and Helena de Puig (right).

Lighting Up Diagnostics

A man wearing a dark blue sweater is smiling and standing in front of a building

When Microbes Meet the Immune System

Methods

A computer-generated image of chromosomes on a black background. One chromosome has a ring of bright orange to indicate a mutation.

Prime Editing Comes of Age

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Glutamate Biosensors Illuminate Talk Between Neurons

This image depicts the fruit fly nerve cord connectome. It highlights 930 neurons, a subset of the full set of reconstructed neurons.

The Expansion of Volume Electron Microscopy

The Literature

A fluorescence microscopy image of a common mouse ear with a black background, an embedded bead visible as a white circle, and regenerating tissue around it shown in green.

Mice Heal Themselves in Response to a Common Signaling Molecule

An elderly person in beige shirt and a knitted, cream-colored vest holds a wooden walking stick.

New Epigenetic Clocks May Confirm Extreme Age

This shows a cryo-EM map of a Fanzor protein in complex with its guiding RNA (in purple) and DNA (target strand in red, complementary strand in blue).

CRISPR-like Abilities in Eukaryotic Proteins

Melanocyte stem cells are shown in red and other cell nuclei are shown in blue.

Hair Turns Gray Due to Stuck Stem Cells

The image shows two adult prairie voles. The voles have a brown coat and are touching each other&rsquo;s snouts.

Molecular Signatures of a Broken Heart

Editorial

A silver tree showing roots and branches in a circle on a blue background.

Onward and Upward!

July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

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Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Twist Bio&nbsp;
Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

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An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

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Explore new strategies for improving plasmid DNA manufacturing workflows.

Overcoming Obstacles in Plasmid DNA Manufacturing

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Products

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Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

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BRANDTECH Scientific Launches New Website for VACUU·LAN® Lab Vacuum Systems

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Waters Enhances Alliance iS HPLC System Software, Setting a New Standard for End-to-End Traceability and Data Integrity 

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Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series