Defying Dogma

Microscopes were inaccessible to most of the world until Manu Prakash and Jim Cybulski put their engineering prowess to the test.

A discovery that goes back to the first studies of translation has become the topic of biotech buzz.

By coloring different organelles simultaneously, cell painting allows scientists to pick up subtle changes in cell function in response to drugs and other perturbations.

Researchers took a mind-bending trip to understand the connections between psychedelic compounds produced by fungi, plants, and humans.

To support thousands of incoming connections, neurons use sophisticated transportation networks for delivering mRNA to faraway regions.

Prime editing is one of the most promising forms of genome editing because it uses only single-stranded DNA breaks.

The sea slug has helped scientists in their quest to understand how neurons encode memories.

A third generation glutamate sensor with a fluorescent readout offers insights into neuronal communication.

Technological advancements over the last two decades transformed volume electron microscopy, improving usability, resolution, and throughput.

Put on your thinking cap, and take on this fun challenge.

Matthew Disney’s idea of small molecules that target RNA once seemed fanciful. Now, even the pharma industry is pursuing it

Brought together by a shared interest in synthetic biology and diagnostics, two researchers are transforming how we label biomolecules.

Timothy Hand leads a research team that explores how maternal immune signals shape the infant intestinal microbiota.

Since the technique was first published in 2019, prime editing has grown with lightning speed, alongside hopes for what it can achieve.

First developed in 2013, a fluorescent indicator has evolved to enable precise glutamate tracking.

A series of technological advancements for automation and parallel imaging made volume electron microscopy more user friendly while increasing throughput.

A newly discovered way to induce scarless healing in mice depends on a highly conserved signaling pathway that is also present in humans.

How will a new version of epigenetic clocks aimed at validating the age of people older than 100 years of age balance accuracy and anonymity?

Two groups independently discovered that Fanzor proteins in eukaryotic organisms are CRISPR’s genome-editing cousins.

Hair-coloring stem cells must swing back and forth between their maturity states to give hair its color.

The transcriptional profiles in the brains of prairie voles changed after a long breakup, revealing a molecular shift that might help them cope with the loss of a partner.

At The Scientist, we are strengthening our roots while reaching for the sky.