These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
L.T. Vassilev et al., "In vivo activation of the p53 pathway by small-molecule antagonists of MDM2,"
This paper is important because it challenges the conventional wisdom that protein-protein interactions are poor drug targets. p53 ... is inhibited when bound by MDM2. ... It is possible to disrupt the p53-MDM2 interaction in cells with a small organic molecule at low micromolar concentrations.
W.C. Winkler et al., "Control of gene expression by a natural metabolite-responsive ribozyme,"
The authors report that glucosamine-6-phosphate (GlcN6P) activates a ribozyme embedded within the 5' untranslated region of the gene encoding its synthesis. This ribozyme cleaves the messenger RNA, thereby suppressing GlcN6P production. ... It will be interesting to see...
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