Largest Seroprevalence Study in US Shows Vast COVID-19 Undercount

Actual cases may be as much as 6 to 24 times higher than reported, but we’re still a long way off from herd immunity.

amanda heidt
| 3 min read
COVID-19, SARS-CoV-2, coronavirus, pandemic, antibodies, seroprevalence, CDC, antibody, testing

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The number of COVID-19 infections nationwide is 6 to 24 times higher than the 3.9 million confirmed cases, according to new data from the US Centers for Disease Control and Prevention.

The results of the new study, published this week (July 21) in JAMA Internal Medicine by CDC researchers and state health officials, represent the largest antibody survey of its kind. Even accounting for these hidden cases detected in 10 cities across the US, the findings suggest that many of the cities are nowhere near the antibody prevalence required for herd immunity. Additionally, scientists are unsure just how long people retain their antibodies after being infected, and what that means for immunity to the disease.

“These data continue to show that the number of people who have been infected with the virus that causes Covid-19 far exceeds the number of reported cases,” Fiona Havers, a CDC ...

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Meet the Author

  • amanda heidt

    Amanda Heidt

    Amanda was an associate editor at The Scientist, where she oversaw the Scientist to Watch, Foundations, and Short Lit columns. When not editing, she produced original reporting for the magazine and website. Amanda has a master's in marine science from Moss Landing Marine Laboratories and a master's in science communication from UC Santa Cruz.
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