When the Immune Response Makes COVID-19 Worse
When the Immune Response Makes COVID-19 Worse
If the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.
When the Immune Response Makes COVID-19 Worse
When the Immune Response Makes COVID-19 Worse

If the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.

If the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.

antibodies
Moderna vs. Pfizer: Is There a “Best” mRNA Vaccine?
Moderna vs. Pfizer: Is There a “Best” mRNA Vaccine?
Alejandra Manjarrez | Sep 24, 2021
Both of the mRNA vaccines available in the US are highly effective against severe COVID-19, but recent studies suggest that Moderna’s elicits a stronger immune response and might be better at preventing breakthrough infections.  
Updated Oct 15
To Booster or Not: Scientists and Regulators Debate
To Booster or Not: Scientists and Regulators Debate
Jef Akst | Sep 16, 2021
President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.
Antibodies Stop Sperm in Their Tracks
Antibodies Stop Sperm in Their Tracks
Abby Olena | Aug 11, 2021
Engineered antibodies trap and immobilize human sperm in the reproductive tract of female sheep, paving the way for possible use as a nonhormonal contraceptive in people.
Mouse Study Suggests Fibromyalgia Has Autoimmune Roots
Mouse Study Suggests Fibromyalgia Has Autoimmune Roots
Annie Melchor | Jul 2, 2021
When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Anthony King | Jul 1, 2021
More than a dozen vaccines for tuberculosis are currently being tested in clinical trials. Some use whole bacteria as BCG does, while others deliver protein subunits or genetic material carried by viral vectors.  
Tuberculosis: The Forgotten Pandemic
Tuberculosis: The Forgotten Pandemic
Anthony King | Jul 1, 2021
This month marks the 100-year anniversary of BCG, still the only approved vaccine against the lethal pathogen. But there are new vaccines for this wily foe on the horizon.
The Quest for a Universal Coronavirus Vaccine
The Quest for a Universal Coronavirus Vaccine
Diana Kwon | Jun 29, 2021
Scientists are on the hunt for a shot that will protect against not only SARS-CoV-2, but other members of its family that may emerge in the future.
Q&A: Human Challenge Studies of COVID-19 Underway in UK
Q&A: Human Challenge Studies of COVID-19 Underway in UK
Jef Akst | Jun 18, 2021
Researchers at Imperial College London and the University of Oxford are exposing healthy volunteers to SARS-CoV-2 for science.
New Evidence Shows COVID-19 Was in US Weeks Before Thought
New Evidence Shows COVID-19 Was in US Weeks Before Thought
Abby Olena | Jun 17, 2021
Some of the blood specimens collected in the United States for the NIH’s All of Us research program starting on January 2, 2020, have antibodies against SARS-CoV-2.
T Cell–Boosting Zika Vaccine Protects Mice from the Virus
T Cell–Boosting Zika Vaccine Protects Mice from the Virus
Ruth Williams | May 12, 2021
By avoiding the production of antibodies, something vaccines ordinarily induce, the immunization sidesteps the problem of antibody-dependent enhancement, which can amplify infection by a similar virus and is known to occur with dengue and Zika.
Pfizer Vaccine Induces Immune Structures Key to Lasting Immunity
Pfizer Vaccine Induces Immune Structures Key to Lasting Immunity
Katarina Zimmer | Mar 25, 2021
In the armpit lymph nodes of people who had received the mRNA vaccine against SARS-CoV-2, researchers found germinal centers needed to generate long-lived antibody-making cells.
COVID-19 Vaccine Combos Aim to Boost Immunity
COVID-19 Vaccine Combos Aim to Boost Immunity
Asher Jones | Mar 9, 2021
Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.
Bispecific Antibodies Treat Cancer in Mouse Models
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena | Mar 5, 2021
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.