Some of the blood specimens collected in the United States for the NIH’s All of Us research program starting on January 2, 2020, have antibodies against SARS-CoV-2.

Engineered viruses that don’t replicate provide a tractable model for scientists to safely study SARS-CoV-2, including research into vaccine efficacy and emerging variants.

Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.

Facing new variants of SARS-CoV-2, some vaccines may offer more robust protection or be more easily redesigned to target them.

SARS-CoV-2 antibodies detected in blood donor samples indicate infections could have occurred in the US more than a month before the first confirmed case, but some experts remain skeptical.

Outcomes in COVID-19 patients may be better in those recently infected with endemic coronaviruses. 

Fewer than 1 in 10 dialysis patients sampled had antibodies against the novel coronavirus as of July, indicating that the greater population is far from levels required to achieve herd immunity.

Adenovirus vectors deliver the genetic instructions for SARS-CoV-2 antigens directly into patients’ cells, provoking a robust immune response. But will pre-existing immunity from common colds take them down?

A study of Nicaraguan children links prior Zika virus infection with aggravated dengue fever symptoms.

An absence of germinal centers—which arise during infections to produce long-lived antibody-generating cells—might explain rapidly waning antibody levels in the disease.

White House officials hail convalescent plasma as a major breakthrough, but scientists say evidence supporting its effectiveness is still lacking.

Researchers say the popularity of convalescent plasma makes it more difficult to gather high-quality data on its efficacy.

In most vertebrates, the absence of adaptive immunity would be catastrophic, but in some deep-sea angler fish species, it enables their “wild” and “wacky” mating habits.