Today Lonza announced a new resource available in the QC Insider™ Toolbox that addresses a key topic of debate in the endotoxin detection community – Low Endotoxin Recovery (LER). Building on Lonza’s comprehensive suite of support tools, a “Low Endotoxin Recovery (LER) - Frequently Asked Questions” Technical Tip sheet has been added to the QC Insider™ Toolbox.
This new tool, in addition to an archived webinar available for viewing, “Low Endotoxin Recovery (LER) – Context and Resolution from a Broad Biologics Test Perspective,” delivers the latest information about this phenomenon and guidance on how QC professionals can better manage LER in their daily work.
LER has been defined as the masking of endotoxin in undiluted biological drug products, such as monoclonal antibodies, vaccines and other protein products, and has been linked to the use of polysorbate in conjunction with a chelating buffer – specifically citrate and phosphate buffers. Lonza’s support ...
