Biochemistry
Biochemistry
B.F. Luisi, W.X. Xu,Z. Otwinowski, L.P. Freedman, et al., "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA," Nature, 352:497, 1991. Ben Luisi (Medical Research Council, Glasgow, U.K.): "The glucocorticoid receptor is activated by its steroid ligand to migrate to the nucleus, where it associates with specific DNA sites and modulates expression of target genes. A small domain in the protein directs the DNA target specificity, and my colleagues and I have det