Immunology
Immunology
C.S. Hsieh, S.E. Macatonia, C.S. Tripp, S.F. Wolf, A. Ogarra, K.M. Murphy, "Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages," Science, 260:547-9, 1993. (Cited in 170 publications through December 1994) Comments by Kenneth M. Murphy This paper describes a mechanism of T-cell development during an immune response; specifically, it deals with the role of the cytokine interleukin 12 (IL-12) in determining which form of the T-helper (TH) population will domina