July 1999

Hemophilia is an ideal model for gene therapy, speaker after speaker repeated during the American Society for Gene Therapy's (ASGT) June meeting in Washington, D.C. Successfully providing a single protein a few times should, in theory, cure the disease, they stated. And once introduced via vector, a therapeutic clotting protein need not be continuously produced or regulated, they added. What they did not mention--at least not as openly--was the double-edged nature of that "ideal" status. In oth

Sometimes it seems as if genome projects are cropping up everywhere.1 But until costs come down, limited resources are being largely concentrated into what Joseph Nadeau, professor of genetics at Case Western Reserve University School of Medicine, calls "the genome seven," an apples-and-oranges list of viruses, bacteria, fungi, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, and mouse, with Homo sapiens in its own category.2 Researchers widely acknowledge that in the rod

Global warming has a strong effect on butterfly populations. Camille Parmesan , assistant professor of integrative biology at the University of Texas in Austin, cares about butterflies, so she's concerned: Global warming is bugging her beloved insects. Three years ago, Parmesan reported that Edith's checkerspot butterfly had moved northward along the west coast of North America over the past century.1 Specifically, local populations were four times more likely to go extinct in Mexico, at the

Foodborne infections and bacterial antibiotic resistance garner tremendous attention in the public health arena. So it should come as no surprise that a decades-long debate is heating up over whether antibiotic-resistant bacteria from food animals pose a threat to humans. Concerned that you just can't keep antibiotic resistance genes down on the farm, the U.S. Food and Drug Administration (FDA) Center for Veterinary Medicine has moved to impose regulations to help curb the development of antibi

William Stetler-Stevenson Find a way to control cell movement, and you've got an excellent weapon in the fights against tumorigenesis and inflammation, an excellent clue as to how organisms develop, and an excellent tool in developing tissue-growth and wound-repair therapies. One particular family of enzymes, called matrix metalloproteinases (MMPs), may hold much of the key to such a weapon. When first studied in the 1940s, matrix degradation was actually more important to the leather indus

if (n == null) The Scientist - From Basic Research to Cancer Drug: The Story of Cisplatin The Scientist 13[14]:11, Jul. 05, 1999 News From Basic Research to Cancer Drug: The Story of Cisplatin By Ricki Lewis Clinical Trial Results for Treating Cervical Cancer The April 15, 1999 issue of The New England Journal of Medicine (NEJM) brought great satisfaction to Barnett Rosenberg, a retired Michigan State University biophysicist who founded the Barros Resear

Date: July 5, 1999Table of Cell Signaling Tools At today's research pace, new signaling mechanisms within and between cells are emerging not one by one but in a chain reaction. Each new discovery has strong implications for previously established models, sometimes overturning several assumptions at once. With such a large number of interacting systems--from cell adhesion to differentiation and apoptosis--and receptor pathways, keeping up with the wealth of cell-signaling research tools can be l

Date: July 5, 1999Products for High-Volume Tissue Culture The Automation Partnership's CELLMATETM Automated Cell Culture Processing System Mammalian cell culture has finally come into its own as a way to produce cells, proteins, or sub-cellular components in large scale. Recent advances in cell culture systems are allowing scientists to better circumvent problems associated with bacterial systems such as incomplete protein expression, toxin contamination, and incompatibility. Today's wide arra