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Editorial

Curiosity Won't Kill Science Classes
Curiosity Won't Kill Science Classes
I'm concerned about the state of science teaching.

Letter

More to Ab specificity than variable region
More to Ab specificity than variable region
I would like to comment on a widespread misunderstanding of immunology by those engaged in engineering mouse-human chimeric antibodies.

Notebook

The eBay of science
The eBay of science
If you're a scientist with some spare time to work on extracurricular projects, there's a company that wants to reward you with as much as $100,000.
10 Euros for a German science academy
10 Euros for a German science academy
The way Detlev Ganten, head of Berlin's Charite University Medical Center, tells the story, he was enjoying dinner in early March at the British Embassy in Berlin with a small group of scientists, when the topic of conversation turned to Germany's lack of a National Academy of Sciences.
A better UK human tissue bill
A better UK human tissue bill
This time last year, the British research community was fuming over a piece of draft legislation that was, in the general view, a potential disaster for science.

Research

An On/Off Switch for Drug Design
An On/Off Switch for Drug Design
In theory, aptamers can specifically bind and modulate the activity of any protein for which they're designed.

Vision

Next Stop, MARS
Next Stop, MARS
This past year President Bush announced a plan for space exploration that includes preparing for a human mission to Mars.

Hot Paper

B Signaling
B Signaling
NEGATIVE FEEDBACK:© AAASNF-κB is held inactive in the cytoplasm by three IκB isoforms. Cell stimulation activates the kinase IKK which leads to phosphorylation and degradation of IκB. This frees NF-κB to enter the nucleus and activate genes including IκBα. IκBβ and -ε are synthesized at a steady rate, allowing for complex temporal control including negative feedback. (From A. Hoffmann et al., Science, 298:1241–5, 2002.)The transcription fac

Briefs

Evidence for organelle origin
Evidence for organelle origin
according to Dutch and German researchers led by Johannes Hackstein of Radboud University Nijmegen in the Netherlands.
Fast track to longevity
Fast track to longevity
Researchers have moved a step forward in understanding how calorie restriction is linked to lifespan extension in mammals.
Interdisciplinary research
Interdisciplinary research
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.S. Cabantous et al., "Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein," Nat Biotechnol, 23:102–7, Jan. 5, 2005.A split [green fluorescent] protein-tagging and detection system was developed that can be easily used in high-throughput screens to obtain soluble, well-folded (recombinant) proteins.
Visa rules relaxed
Visa rules relaxed
In a move to enhance US economic competitiveness, the State Department in February extended the period for visa security clearances for non-US citizens working in "sensitive areas," such as chemistry, pharmacology, and engineering.
NIH scientists challenge stock ownership, consulting rules
NIH scientists challenge stock ownership, consulting rules
A group that represents senior scientists and others at the National Institutes of Health is proposing less restrictive regulations concerning the ownership of stock in drug and biotech companies, and the ability to consult with universities and academic institutions.

Technology

Gene Finding with Hidden Markov Models
Gene Finding with Hidden Markov Models
made history in 1995 when it became the first free-living organism to have its genome completely sequenced.
Glycomics Researchers Search for the Elusive Sweet Spot
Glycomics Researchers Search for the Elusive Sweet Spot
Cells are coated with carbohydrates, as are many of the proteins and lipids contained within cells.
Squeeze More from Your Samples
Squeeze More from Your Samples
In the mid-1990s, toxicologist Raymond Biagini was looking for a faster way to evaluate pest-control workers for exposure to pesticides.

Tools and Technology

Human Epigenome Project Maps MHC Locus
Human Epigenome Project Maps MHC Locus
Methylation at regulatory regions, especially promoters, correlates with transcriptional activity: Sequences near silent genes generally are methylated, whereas those near active regions are not.
Musclebots
Musclebots
Microrobots and other miniature machines all have the same problem: Where do you plug them in?
A Spoonful of Nano Helps the Medicine Go Down
A Spoonful of Nano Helps the Medicine Go Down
A new nanotech-enabled drug recently approved by the US Food and Drug Administration promises to make life a little easier for patients with breast cancer.

BioBusiness

When Science Switches Shores
When Science Switches Shores
Since the New York City life science technology-consulting firm Intrasphere Technologies opened an office in India, Samuel Goldman, cofounder and chief technology officer, says he works fairly bizarre hours, scheduling 6:00 A.M. meetings on a "regular basis."
Legislating Stem Cells
Legislating Stem Cells
Legislating Stem Cells
Kenneth Giacin couldn't be more excited about California's Proposition 71.
Malaria, Science, and Social Responsibility
Malaria, Science, and Social Responsibility
A problem that has seemed intractable for decades may finally be cracking: How to create affordable drug therapies for people who don't offer pharmaceutical companies a commercial market?

Atlas

Focus on Berlin
Focus on Berlin
If you ask Detlev Ganten whether he would like to see Berlin develop into a global life science center in coming years, he will say "no."

Closing Bell

In Search of Bugs
In Search of Bugs
In Search of Bugs
Premieres on PBS, April 17.