September 1999

When Paul R. Sanberg became a neuroscientist, he focused on Huntington's disease. When he realized that Parkinson's disease was related, he expanded his horizons. And when his father suffered a stroke about five years ago, he shifted his priorities. Some of the things he has learned since may help treat all three diseases, as well as a number of other neurodegenerative disorders. Following his father's stroke, Sanberg recalls months of trips between Tampa, where he worked as a researcher for t

It's a simple but haunting question: Can microgravity influence gene expression? Yes, according to a recent study of human cells conducted aboard NASA's space shuttle. In fact, the results are so promising that the investigators believe their continuing research could lead to better toxicology tests, key elements of tissue engineering, and new treatments for various diseases--while broadening the scope of scientific experimentation. Astronaut Katherine P. Hire works with the bioreader system

A scene from the Missouri Botanical Garden The saying "if you want something done, give it to a busy person" fits Peter Raven like a glove. Director of the Missouri Botanical Garden since 1971, home secretary of the National Academy of Sciences, and author of textbooks in biology and botany, Raven hosted about 5,000 scientists from more than 100 countries as president of the XVI International Botanical Congress in St. Louis August 1-7. With Harvard University's Edward O. Wilson, Raven is biodi

For about a decade, Susan Swedo, chief of the Pediatric and Developmental Neuropsychiatry Branch of the National Institute of Mental Health (NIMH), has been investigating how an ordinary strep infection can trigger an autoimmune response leading to obsessive-compulsive disorder (OCD). She, her colleagues at NIMH, and other researchers have been exploring this link with a goal of better understanding the role of the brain in mental disorders and developing better OCD treatments. Though strep is

At the recent theme symposium of the 1999 International Joint Conference on Neural Networks held in Washington, D.C., neurobiologists, psychologists, and engineers presented a wide variety of research projects attempting to make sense of the human brain. But despite the variance among disciplines and approaches, the symposium, entitled "Neuronal Ensembles: Paradigm Shifts in Cognitive Modeling," had a common thread: elucidating brain function by examining the behavior of groups of neurons rathe

Brain development is an awesome feat. Over a trillion neurons make connections with thousands of target cells to create coherent circuits for vision, language, movement, and memory. Most neurons migrate from their birthplace to their permanent home in the developing brain. Once they find a home, some cells send growth cones to different parts of the brain, creating networks with their axons. Corey Goodman, professor of molecular biology at the University of California, Berkeley, elaborates, "Th

Courtesy of Alan Whanger Facial image of the Man of the Shroud surrounded by "the ghost of flowers past." The topic of the last press conference on Monday, August 2, at the XVI International Botanical Congress in St. Louis seemed to have a nice mix of classical scientific observation, image analysis, and palynology (pollen identification), as well as great historical interest. A team led by Avinoam Danin, a professor of evolution, systematics, and ecology at the Hebrew University of Jerusalem

Neuronal precursors from a particular region of the ventral forebrain--the medial ganglionic eminence (MGE)--are capable of migrating extensively in both the embryonic and adult brain and differentiating into neurons in several brain regions, researchers at Rockefeller University reported recently. The study adds more evidence to the viability of cell transplantation as a treatment for neurogenerative disorders and brain damage.1 "We are for the first time identifying a new population of cells

Edited by: Paul Smaglik M. Citron, D. Westaway, W.M. Xia, G. Carlson, T. Diehl, G. Levesque, K. Johnson-Wood, M. Lee, P. Seubert, A. Davis, D. Kholodenko, R. Motter, R. Sherrington, B. Perry, H. Yao, R. Strome, I. Lieberburg, J. Rommens, S. Kim, D. Schenk, P. Fraser, P.S. Hyslop, D.J. Selkoe, "Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid ß protein in both transfected cells and transgenic mice, Nature Medicine, 3:67-72, January 1997. (Cited in more th

Edited by: Paul Smaglik M. DiFiglia, E. Sapp, K.O. Chase, S.W. Davies, G.P. Bates, J.P. Vonsattel, N. Aronin, "Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain," Science, 277:1990-3, 1997. (Cited in more than 200 papers since publication) Neil Aronin Comments by Neil Aronin, professor of medicine and cell biology, Massachusetts Medical Center, Worcester, Mass. The pathogenic connection between huntingtin the protein and Huntington's the disease

Date: September 13, 1999Table of Neurochemical Manufacturers The hypothalamus has long been known as a control center for feeding and weight control behaviors. Complex regulatory feedback loops enable this portion of the brain to determine satiety and metabolic activity. Not surprisingly, the control mechanisms are complex and involve different biochemical pathways.1,2,3 Image courtesy of Jeffrey M. Friedman An ob/ob mouse stacking up against its lean counterparts A series of pioneering expe

Date: September 13, 1999Cell Separation Products Magnetic Cell Separation Technologies that isolate rare cell types to high purity are essential to the cell biology researcher. Understanding cell developmental pathways becomes increasingly significant as diagnosis and treatment of disease turns more to the molecular level.1 This diagnosis of cell-related diseases requires methods for detection, isolation, and analysis of individual cells regardless of their frequency.2 The hematopoietic system

if (n == null) The Scientist - Georgia Gets New Neuroscience Center The Scientist 13[18]:26, Sep. 13, 1999 Profession Georgia Gets New Neuroscience Center By Steve Bunk Reductionist science is overemphasized, declares zoologist Pat Marsteller, director of the Hughes Undergraduate Program at Emory University. "As my grandfather would say, they're learning more and more about less and less until they know everything about nothing." What's needed now, she thi

if (n == null) The Scientist - Neurosciences Offer Researchers Diverse Opportunities The Scientist 13[18]:26, Sep. 13, 1999 Profession Neurosciences Offer Researchers Diverse Opportunities By James Kling Great promise for advances in neuroscience existed at the beginning of the Decade of the Brain. Like most life science disciplines, neuroscience had benefited from huge strides in molecular biology, and many expected neuromuscular diseases such as multipl