Big science, with very few exceptions (one being the Human Genome Project), is a waste of money.1 Big science is grossly inefficient, and is designed to impress non-scientists (including university administrators). Anyone who has experienced the difference between forced collaborations (big science) and real collaborations (spontaneous, as-needed interactions) knows this is true.
Basic research does lead to cures for diseases as well as other improvements in quality of life. Big science enriches a few empire builders but produces nothing.
Contrary to Steven Wiley's claim, Congress does not respond to the voters. The voters have said for decades they want more money spent on medical research. Congress responds to lobbyists and they respond to money. We need better lobbyists.
Biomedical research in the United States is now in a state of crisis from which it may not recover. Diverting money from real science into flashy projects may fool a few politicians ...
