L.-H. Tsai, E. Harlow, M. Meyerson, "Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase," Nature, 353:174-7, 1991.
Li-Huei Tsai (Massachusetts General Hospital Cancer Center, Charlestown, Mass.): "Regulation of the onset of cellular DNA synthesis appears to be an important mechanism for small DNA tumor viruses to immortalize cells. Both the retinoblastoma gene product (pRB) and cyclin A, two of the adenovirus E1A targeted cellular proteins, have been shown to play critical roles in cell-cycle regulation in several labs. p33cdk2 was first noticed by its association with E1A as well as cyclin A. We have cloned the gene encoding p33cdk2 and showed that it shares significant homology with p34cdk2, a protein kinase that regulates cell-cycle progression in all eukaryotic organisms. In addition, several laboratories have reported that cdk2 kinase is able to perform the cdc2 function in yeasts harboring an inactivated cdc2 kinase.
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