Mouse Study Catalogs Gene Functions

A European consortium identifies phenotypes for 320 genes, assigning new functions for half.

Written byAmanda B. Keener
| 1 min read

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WIKIMEDIA, RAMA

Researchers have assigned phenotypes to around 150 mouse genes, according to a study published in Nature Genetics this week (July 27). An international group of scientists working with the European Mouse Disease Clinic (EUMODIC) altered 320 genes within individual mouse lines and put the animals through a battery of tests to understand what each gene did. About half of those genes were previously of unknown function.

“The standardized practices that have been developed through this research allow multiple centers to work in concert to generate robust, reproducible data,” study coauthor David Adams, a geneticist at the Wellcome Trust Sanger Institute said in a statement. “In the long term, this streamlined approach and the availability of the data from these studies will significantly reduce the number ...

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