white adult mouse with 4 pups on white background
Mice that Survive Infection Pass on Stronger Immunity
Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.
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Mice that Survive Infection Pass on Stronger Immunity
Mice that Survive Infection Pass on Stronger Immunity

Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.

Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.

ABOVE: ISTOCK.COM, ANYAIVANOVA
mouse research
Photograph of a mouse covering his face with his paw.
Bless You: Mouse Model Reveals Molecular Pathway Behind Sneezing
Amanda Heidt | Oct 1, 2021
Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.
Illustration showing how a mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
Infographic: The Neural Pathway of Sneezing
Amanda Heidt | Oct 1, 2021
A mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
Immunofluorescence image of human tenocytes (cell nuclei in blue, actin in red) with PIEZO1 protein labeled in green (Scale bar: 20 ?m)
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Catherine Offord | Sep 1, 2021
Researchers identify a role for PIEZO1 in tendon adaptation, and show that people with certain versions of the Piezo1 gene tend to be better jumpers.
One hand holds a white envelope with a blue and red striped border, while a second hand places a clear sheet of plastic inside with small squares of paper on it
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
A black mouse runs on a yellow and green spinning wheel against a blue background
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
Two oligodendrocyte progenitor cells are being generated from adult stem cells nestled on the surface of brain ventricle
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Amanda Heidt | Jun 10, 2021
A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
Ashley Yeager | Oct 1, 2020
Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Abby Olena | May 14, 2020
Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Abby Olena | Mar 27, 2020
Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.
Chemosensory Cells in the Nose Play a Role in Allergic Reactions
Abby Olena | Jan 17, 2020
In mice, a group of nasal epithelial cells called brush cells release pro-inflammatory signals in response to allergens.
The Influence of Soil on Immune Health
Jef Akst | Jan 8, 2020
Recent work in humans and mice highlights how exposure to environmental microbes helps protect against allergies and other inflammatory diseases.
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Abby Olena | Sep 19, 2019
Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.
tweaking microbiome composition reduces colorectal tumor growth in mice
Image of the Day: Tamed Gut Bacteria
Nicoletta Lanese | Aug 8, 2019
Curbing the growth of harmful bacteria in mouse microbiomes reduces the animals’ incidence of inflammation-related colorectal cancer.
mouse microbiome
Mouse Genetics Shape the Gut Microbiome More than Their Environment
Nicoletta Lanese | Aug 6, 2019
Neither the maternal microbiome nor housing conditions appear to permanently alter which microbes remain in the animals.
Brain’s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Abby Olena | Jul 24, 2019
Detailed imaging of the rodent central nervous system reveals new information about the route cerebrospinal fluid takes to leave the brain.
a black mouse held in a gloved hand
Prominent Mouse Genetics Center Could be Shuttered
Shawna Williams | Jun 21, 2019
Staff at the UK’s Harwell Institute were notified that a strategy board recommended halting its academic work, but a final decision is months away.
Image of the Day: Life and Death
Carolyn Wilke | Mar 22, 2019
When hair follicle stem cells lose their protein-based death cue, they take on a new role helping to repair wounds in skin.
CAR T Cells Treat Lupus in Mice
Abby Olena | Mar 6, 2019
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.
notebook
An Algorithm to Predict the Age of Your Lab Mice
Anthony King | Feb 1, 2019
Researchers develop an app that can estimate the biological age of a rodent from its mug shot—and could give a boost to the science of human aging in the process.