Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Scientists Discover “Gorditas” and Other Novel Brain Cell Types

A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.

A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.

mouse research
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
Ashley Yeager | Oct 1, 2020
Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Abby Olena | May 14, 2020
Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Abby Olena | Mar 27, 2020
Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.
Chemosensory Cells in the Nose Play a Role in Allergic Reactions
Chemosensory Cells in the Nose Play a Role in Allergic Reactions
Abby Olena | Jan 17, 2020
In mice, a group of nasal epithelial cells called brush cells release pro-inflammatory signals in response to allergens.
The Influence of Soil on Immune Health
The Influence of Soil on Immune Health
Jef Akst | Jan 8, 2020
Recent work in humans and mice highlights how exposure to environmental microbes helps protect against allergies and other inflammatory diseases.
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Abby Olena | Sep 19, 2019
Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.
Image of the Day: Tamed Gut Bacteria
Image of the Day: Tamed Gut Bacteria
Nicoletta Lanese | Aug 8, 2019
Curbing the growth of harmful bacteria in mouse microbiomes reduces the animals’ incidence of inflammation-related colorectal cancer.
Mouse Genetics Shape the Gut Microbiome More than Their Environment
Mouse Genetics Shape the Gut Microbiome More than Their Environment
Nicoletta Lanese | Aug 6, 2019
Neither the maternal microbiome nor housing conditions appear to permanently alter which microbes remain in the animals.
Brain’s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Brain’s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Abby Olena | Jul 24, 2019
Detailed imaging of the rodent central nervous system reveals new information about the route cerebrospinal fluid takes to leave the brain.
Prominent Mouse Genetics Center Could be Shuttered
Prominent Mouse Genetics Center Could be Shuttered
Shawna Williams | Jun 21, 2019
Staff at the UK’s Harwell Institute were notified that a strategy board recommended halting its academic work, but a final decision is months away.
Image of the Day: Life and Death
Image of the Day: Life and Death
Carolyn Wilke | Mar 22, 2019
When hair follicle stem cells lose their protein-based death cue, they take on a new role helping to repair wounds in skin.
CAR T Cells Treat Lupus in Mice
CAR T Cells Treat Lupus in Mice
Abby Olena | Mar 6, 2019
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.
An Algorithm to Predict the Age of Your Lab Mice
An Algorithm to Predict the Age of Your Lab Mice
Anthony King | Feb 1, 2019
Researchers develop an app that can estimate the biological age of a rodent from its mug shot—and could give a boost to the science of human aging in the process.
Image of the Day: Mouse Tails
Image of the Day: Mouse Tails
Carolyn Wilke | Jan 24, 2019
Genetic mutations create lab mice with unusually long and short tails.
First Successful Gene Drive in Mammals
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
Infographic: Behind Mouse Eyes
Infographic: Behind Mouse Eyes
Ruth Williams | Nov 1, 2018
A mesh records retinal cells’ firings in live animals.
First Mouse Embryos Made from Two Fathers
First Mouse Embryos Made from Two Fathers
Abby Olena | Oct 11, 2018
The bipaternal pups died soon after birth, but mice with two mothers grew into fertile adults.
Study Challenges CRISPR Method for Making Conditional Knockout Mice
Study Challenges CRISPR Method for Making Conditional Knockout Mice
Sukanya Charuchandra | Sep 28, 2018
Researchers from 17 labs report low efficacy rates for the popular technique.
Cancer Cells Fuse with Immune Cells in Human Patients
Cancer Cells Fuse with Immune Cells in Human Patients
Anna Azvolinsky | Sep 13, 2018
The hybrid cells promote tumor heterogeneity and possible metastasis, a new study in mice and humans shows.