mouse research

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.

An independent lab fails to replicate results suggesting mammals exposed to pathogens could pass on immunological protections through epigenetic mechanisms.

Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.

Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.

A mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.

Researchers identify a role for PIEZO1 in tendon adaptation, and show that people with certain versions of the Piezo1 gene tend to be better jumpers.

Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.

Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.

A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.

Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.

Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.

Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.

In mice, a group of nasal epithelial cells called brush cells release pro-inflammatory signals in response to allergens.

Recent work in humans and mice highlights how exposure to environmental microbes helps protect against allergies and other inflammatory diseases.

Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.

Curbing the growth of harmful bacteria in mouse microbiomes reduces the animals’ incidence of inflammation-related colorectal cancer.

Neither the maternal microbiome nor housing conditions appear to permanently alter which microbes remain in the animals.

Detailed imaging of the rodent central nervous system reveals new information about the route cerebrospinal fluid takes to leave the brain.