N-of-1 Trials Take on Challenges in Health Care

From personalizing clinical practice to aiding biomedical research, individualized clinical trials have been heralded as a solution to several problems plaguing modern medicine. But they’ve yet to be widely adopted.

Written byCatherine Offord

| 15 min read

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For a few months in the first half of 2019, Chris Payze started each morning at home in Queensland, Australia, by jotting down answers to a series of questions. What time did I go to bed? How many times did I wake up? Speaking to The Scientist this April, 71-year-old Payze said she’d gotten “really into the groove” of this daily routine. “It only takes me about five minutes.”

She recorded the information for a trial of melatonin, a hormone that regulates sleep-wake cycles and is often taken orally as a sleep aid, although it’s not clear how well it works. Payze has Parkinson’s disease, and for the last couple years, she, like many people with the condition, has been dealing with insomnia. “I just have awful trouble sleeping at night,” she explains. While she doesn’t feel sleep-deprived, the interrupted sleep “is just annoying me. ...

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Meet the Author

Catherine Offord
After undergraduate research with spiders at the University of Oxford and graduate research with ants at Princeton University, Catherine left arthropods and academia to become a science journalist. She has worked in various guises at The Scientist since 2016. As Senior Editor, she wrote articles for the online and print publications, and edited the magazine’s Notebook, Careers, and Bio Business sections. She reports on subjects ranging from cellular and molecular biology to research misconduct and science policy. Find more of her work at her website.
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