N-of-1 Trials Take on Challenges in Health Care

From personalizing clinical practice to aiding biomedical research, individualized clinical trials have been heralded as a solution to several problems plaguing modern medicine. But they’ve yet to be widely adopted.

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N-of-1 trials

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For a few months in the first half of 2019, Chris Payze started each morning at home in Queensland, Australia, by jotting down answers to a series of questions. What time did I go to bed? How many times did I wake up? Speaking to The Scientist this April, 71-year-old Payze said she’d gotten “really into the groove” of this daily routine. “It only takes me about five minutes.”

She recorded the information for a trial of melatonin, a hormone that regulates sleep-wake cycles and is often taken orally as a sleep aid, although it’s not clear how well it works. Payze has Parkinson’s disease, and for the last couple years, she, like many people with the condition, has been dealing with insomnia. “I just have awful trouble sleeping at night,” she explains. While she doesn’t feel sleep-deprived, the interrupted sleep “is just annoying me. ...

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Meet the Author

  • Catherine Offord

    Catherine is a science journalist based in Barcelona.

Published In

On Target July Issue The Scientist
July/August 2019

On Target

Researchers strive to make individualized medicine a reality

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