Unisyn Technologies, based in San Diego, has introduced Hybrid Grow specialized basal medium for growing hybridomas in the company's Cell-Pharm hollow-fiber bioreactors. The medium elevates glucose and glutamine levels to deliver nutrients to the tissue-dense hollow-fiber hybridoma cultures. According to Unisyn, Hybrid Grow simplifies downstream processing and reduces regulatory concerns because it is free of bovine products. Addition of defined medium supplements to the product increases production rates in serum-free environments, the company says. Hybrid Grow does not contain pherol red, which can interfere with charged-based separation media, such as ion-exchange gels.
Unisyn notes that Hybrid Grow is produced in a Class 100 clean room in compliance with Food and Drug Administration Good Manufacturing Practices using water tested against USPXXII Water-for-Injection standards. It is also dispensed through filling equipment that sterilizes filling ports between each use.
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