Reevaluating Sex Reassignment

Graphic: Cathleen Heard Results of two studies from the Johns Hopkins Children's Center challenge accepted medical practice of "sex reassignment"--surgically converting XY males with absent or minuscule penises into anatomical females, then raising them as girls. The investigations, which are the first to go beyond individual case reports, reveal outcomes that are remarkably consistent with rare instances of infants who lost their penises in accidents and who were reassigned as females. Both cli

| 8 min read

Register for free to listen to this article
Listen with Speechify
0:00
8:00
Share

Graphic: Cathleen Heard
Results of two studies from the Johns Hopkins Children's Center challenge accepted medical practice of "sex reassignment"--surgically converting XY males with absent or minuscule penises into anatomical females, then raising them as girls. The investigations, which are the first to go beyond individual case reports, reveal outcomes that are remarkably consistent with rare instances of infants who lost their penises in accidents and who were reassigned as females. Both clinical trials and case reports powerfully argue for nature over nurture in establishing gender identity.

William Reiner, a child and adolescent psychiatrist and urologist at the Johns Hopkins Children's Center, reported the studies at the Lawson Wilkins Pediatric Endocrine Society meeting in Boston on May 12, 2000. "These children demonstrate that normal male gender identity can develop not only in the absence of the penis, but even after the removal of the testicles and unequivocal rearing as female. ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Ricki Lewis

    This person does not yet have a bio.

Published In

Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

fujirebio-square-logo

Fujirebio Receives Marketing Clearance for Lumipulse® G pTau 217/ β-Amyloid 1-42 Plasma Ratio In-Vitro Diagnostic Test

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours