Old cells may regain a youthful phenotype when exposed to a young cell environment, say researchers in
"We know old tissue repairs poorly, but it's not because there aren't stem cells ready to do the repair," coauthor Thomas Rando told
To study how systemic factors affect satellite cell regeneration, researchers from Stanford University and VA Palo Alto Health Care System in California created fusions of the circulatory systems of old mice and young mice—a technique known as parabiosis. The young mice were transgenic, expressing either green florescent protein or a distinct CD45 allele.
Five days after injuring the mice's hindlimbs, researchers found nucleated embryonic myosin heavy chain, a specific marker...