For this article, Jim Kling interviewed Louis M. Staudt, senior investigator, Center for Cancer Research, National Cancer Institute; and Michael Bittner, a researcher with the National Human Genome Research Institute. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

A.A. Alizadeh et al., "Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling," Nature, 403:503-11, Feb 3, 2000. (Cited in 351 papers)

M. Bittner et al., "Molecular classification of cutaneous malignant melanoma by gene expression profiling," Nature, 406:536-40, Aug. 3, 2000. (Cited in 107 papers)

©2001 MacMillan Magazines Ltd.

Melanoma Exposed: Variation in biological properties of melanoma clusters. a-c, shows a representative member of the major melanoma cluster (UACC-1022). d-f, shows a sample falling outside of the major cluster (M93-047). (Reprinted with permission...

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