RNA Timeline: A History in Hybridization and Structure

RNA Timeline: A History in Hybridization and Structure Alexander Rich and David Davies discover the double-stranded RNA helix and show that polyribo U and polyribo A hybridize spontaneously.6 Ben Hall and Sol Speigelman carry out DNA-RNA hybridization in viral infected bacterial system.15 Rich and colleagues publish on two RNA double helix fragments solving the structure at atomic re

Written byAlexander Rich

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Ben Hall and Sol Speigelman carry out DNA-RNA hybridization in viral infected bacterial system.¹⁵

Rich and colleagues publish on two RNA double helix fragments solving the structure at atomic resolution.^{9, 10}

Stanley Cohen, Herbert Boyer and colleagues construct the first biologically functional, recombinant bacterial plasmids through hybridization of sticky ends.

Kary Mullis develops PCR, publishing his work in 1985 (see p. 92).

Rich discovers the DNA-RNA hybrid helix.¹³

Paul Doty and Julius Marmur discover annealing of DNA allowing nucleotides with different sequences to hybridize.¹⁴

Richard Jorgensen and colleagues first note co-suppression of a gene in petunia plants.

References 1. J.D. Watson, F.H.C. Crick, "A structure for deoxyribose nucleic acid," Nature, 171:738-40, 1953. 2. D.M. Brown, A.R. Todd, "Nucleotides, Part IX. Some observations on the structure and chemical behaviour of the nucleic acids," J Chem Soc, 52-8, 1952. 3. A. Rich, J.D. Watson, "Some relations between DNA and RNA," Proc Natl ...

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