WIKIMEDIA, UWE GILLE
TAF4b, a gonad-specific protein critical for mouse fertility, is not only required for long-term sperm production, but also plays a role in maintaining a population of spermatogonial stem cells, according to a study published last week (February 28) in Stem Cells.
Previous work had shown that female mice lacking the gene encoding the transcription factor TAF4b are infertile due to ovaries that age too quickly, while male mice without TAF4b are initially fertile, but stop producing sperm at the age of three months instead of the normal two years. To understand why, researchers at Brown University and the University of Amsterdam examined how sperm cells and their precursors developed in mice lacking the gene.
The scientists found that even during embryonic development, mice without functional ...
