Stimulants Fail to Stimulate?

Caffeine and amphetamine don't always help rats work harder at tests of mental effort. It depends on their work ethic.

Written byRuth Williams
| 3 min read

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WIKIMEDIA COMMONS, JOANNA SERVAES

The extent to which individuals are willing to make an effort at cognitive tasks may alter their reaction to psychostimulants, a new study in rats suggests. The work, published today (March 28) in Neuropsychopharmacology, shows that while lackadaisical rats concentrate harder if given amphetamine, the drug makes hard-working rats ease off. The rats' work ethics also altered their responses to caffeine.

Such studies are important because, in humans, an unwillingness to exert cognitive effort, called recruiting effort impairment by psychologists, can be symptomatic of underlying psychological disorders. "Impairment in recruiting effort shows up in a lot of different illnesses—post-traumatic stress disorder, depression, brain injury, ADHD, that sort of thing," says Jay Hosking of the University of British Columbia in Vancouver, a lead author of the ...

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  • ruth williams

    Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.

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