alternative splicing

Enhancing protein diversity and guiding cellular functions, alternative splicing is a key dimension of genetic regulation.

During her routine tasks in the laboratory, Mallory Havens suddenly found herself navigating a toxic terrain. 

Cohesin mutations cause dysregulations in alternative splicing, contributing to tumor initiation and progression, a study finds. 

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

The way in which mRNA transcripts are cut can influence the elasticity of the organ.

It’s now clear that gene transcripts can be constructed in various ways, yet many questions remain about the process.

Meet some of the people featured in the January/February 2020 issue of The Scientist.

Two studies contest the idea that the noncoding sequences are just “junk DNA,” demonstrating that they play important roles in the regulation of cell growth.

A proposed mechanism for how bearded dragons with male chromosomes hatch as females at high temperatures

At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.

Mice born with lower amounts of nSR100 protein display the symptoms of autism spectrum disorder, suggesting a functional link.

Proteins encoded by the same gene can play very different roles in the cell, scientists show.

Additions to the bases of RNA molecules can be written, read, and erased.

Converting heart muscle to pacemaker cells in pigs; alternative splicing and the human proteome; questioning a reported yogurt mold-illness link; H. pylori swiftly find mouse stomach injuries

Comparing gene transcripts from different species reveals surprising splicing diversity.

New research suggests that circular RNA transcripts are not as rare as previously thought.