A photograph of Christine Guthrie with former students James Umen and Hiten Madhani
RNA Pioneer Christine Guthrie Dies at 77
Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.
RNA Pioneer Christine Guthrie Dies at 77
RNA Pioneer Christine Guthrie Dies at 77

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

alternative splicing
Infographic: How Splicing of Genes Can Affect Heart Health
Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice | Jan 13, 2020
The way in which mRNA transcripts are cut can influence the elasticity of the organ.
a pair of scissors cuts a film strip that's curled into a helix
Alternative Splicing Provides a Broad Menu of Proteins for Cells
Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice | Jan 13, 2020
It’s now clear that gene transcripts can be constructed in various ways, yet many questions remain about the process.
Contributors
The Scientist Staff | Jan 13, 2020
Meet some of the people featured in the January/February 2020 issue of The Scientist.
A New Role for Yeast Introns: Helping Cells Cope Under Stress
Katarina Zimmer | Jan 16, 2019
Two studies contest the idea that the noncoding sequences are just “junk DNA,” demonstrating that they play important roles in the regulation of cell growth.
Sex Reversal Mystery Explained?
Jef Akst | Jun 15, 2017
A proposed mechanism for how bearded dragons with male chromosomes hatch as females at high temperatures
Angela Brooks: Splicing Specialist
Diana Kwon | Apr 1, 2017
At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.
Shortage of a Protein Linked to Autism in Mice
Joshua A. Krisch | Dec 19, 2016
Mice born with lower amounts of nSR100 protein display the symptoms of autism spectrum disorder, suggesting a functional link.
Same Gene, Different Functions
Catherine Offord | Feb 11, 2016
Proteins encoded by the same gene can play very different roles in the cell, scientists show.
RNA Methylation Dynamics
and Gidi Rechavi, Dan Dominissini, and Chuan He | Dec 31, 2015
Additions to the bases of RNA molecules can be written, read, and erased.
Week in Review: July 14–18
Tracy Vence | Jul 18, 2014
Converting heart muscle to pacemaker cells in pigs; alternative splicing and the human proteome; questioning a reported yogurt mold-illness link; H. pylori swiftly find mouse stomach injuries
Evolution by Splicing
Ruth Williams | Dec 20, 2012
Comparing gene transcripts from different species reveals surprising splicing diversity.
RNA Chases Its Tail
Sabrina Richards | Feb 2, 2012
New research suggests that circular RNA transcripts are not as rare as previously thought.