Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss

A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.

A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.

amyloid plaques
Yeast Models Provide New Insights into Neurodegenerative Diseases
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Lisa Winter | Mar 16, 2021
Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Iconoclastic Alzheimer’s Researcher Robert Moir Dies
Iconoclastic Alzheimer’s Researcher Robert Moir Dies
Shawna Williams | Jan 2, 2020
The 58-year-old was best known for uncovering evidence of a link between pathogens and the neurodegenerative disease.
<em>APOE</em> Mutation Linked to Protection From Alzheimer&rsquo;s: Case Study
APOE Mutation Linked to Protection From Alzheimer’s: Case Study
Catherine Offord | Nov 5, 2019
A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.
Alzheimer&rsquo;s-Related Protein Can Spread by Tainted Growth Hormone
Alzheimer’s-Related Protein Can Spread by Tainted Growth Hormone
Carolyn Wilke | Dec 14, 2018
A hormone treatment contaminated with amyloid-β given to mice caused the protein’s accumulation in their brains, suggesting the same could have occurred in humans given the therapy.
Microglia Remember Bouts of Bodily Inflammation in Mice
Microglia Remember Bouts of Bodily Inflammation in Mice
Ashley Yeager | Apr 11, 2018
A new study reports that immune memory may contribute to neurodegenerative diseases.
Tau Production Increased in Alzheimer’s Patients
Tau Production Increased in Alzheimer’s Patients
Jim Daley | Mar 21, 2018
The findings suggest that faster synthesis, rather than decreased clearance, causes the protein to build up in neurons.
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Catherine Offord | Feb 1, 2018
The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.
Do Microbes Trigger Alzheimer’s Disease?
Do Microbes Trigger Alzheimer’s Disease?
Jill U. Adams | Sep 1, 2017
The once fringe idea is gaining traction among the scientific community.
Toward Treating Alzheimer’s Disease with Brain Waves
Toward Treating Alzheimer’s Disease with Brain Waves
Ashley P. Taylor | Dec 7, 2016
In a mouse model, researchers mitigated three Alzheimer’s disease–associated symptoms by stimulating gamma waves with light.
More Evidence of Alzheimer’s Transmission
More Evidence of Alzheimer’s Transmission
Jef Akst | Jan 27, 2016
Examining the brains of seven patients who died of the prion disease called Creutzfeldt–Jakob, researchers find signs of Alzheimer’s pathology. 
Delayed Turnover
Delayed Turnover
Amanda B. Keener | Jul 21, 2015
Aggregate-forming amyloid β proteins are replenished more slowly with age, and this may contribute to a person's risk of developing Alzheimer’s disease.
Shoring Up Golgi To Slow Alzheimer’s
Shoring Up Golgi To Slow Alzheimer’s
Kerry Grens | Dec 8, 2014
Blocking activity of a kinase in a mouse model protects Golgi in cells and reduces the build-up of amyloid β, a primary component of Alzheimer’s disease.
Week in Review: May 12–16
Week in Review: May 12–16
Tracy Vence | May 16, 2014
Antidepressant could prevent Alzheimer’s plaques; 12,000-year-old human skeleton sequenced; disentangling the mystery of octopus arms; taking a look at the ocular microbiome
Autophagy’s Role in Alzheimer’s
Autophagy’s Role in Alzheimer’s
Abby Olena | Oct 3, 2013
Researchers show that amyloid beta is secreted from neurons in an autophagy-dependent manner.
Cancer Drug for Alzheimer’s Disappoints
Cancer Drug for Alzheimer’s Disappoints
Kate Yandell | May 24, 2013
Researchers have been unable to reproduce findings that a cancer drug destroys amyloid beta plaques.
Restless Nights Predict Alzheimer’s?
Restless Nights Predict Alzheimer’s?
Dan Cossins | Oct 18, 2012
Researchers find that disrupted sleep-wake cycles could reflect or even contribute to the neurodegenerative disease.