Illustration of light blue neurons with white amyloid plaques accumulating on their axons.
New Alzheimer’s Drug Slows Cognitive Decline in Clinical Trial
The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.
New Alzheimer’s Drug Slows Cognitive Decline in Clinical Trial
New Alzheimer’s Drug Slows Cognitive Decline in Clinical Trial

The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.

The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.

amyloid plaques
An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left). Scale bar 50 µm.
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Catherine Offord | Dec 1, 2021
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
Colored artistic rendition of neurons and plaque buildup
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Chloe Tenn | Oct 8, 2021
A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.
LabTalk Podcast - Understanding Microglial Response in Alzheimer’s Disease
The Scientist Creative Services Team and 10x Genomics
Single-cell technologies reveals subpopulations of microglia that play distinct roles in diseased and healthy brains.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Lisa Winter | Mar 16, 2021
Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.
a patient getting blood drawn for testing
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Robert Moir
Iconoclastic Alzheimer’s Researcher Robert Moir Dies
Shawna Williams | Jan 2, 2020
The 58-year-old was best known for uncovering evidence of a link between pathogens and the neurodegenerative disease.
APOE Mutation Linked to Protection From Alzheimer’s: Case Study
Catherine Offord | Nov 5, 2019
A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.
Alzheimer’s-Related Protein Can Spread by Tainted Growth Hormone
Carolyn Wilke | Dec 14, 2018
A hormone treatment contaminated with amyloid-β given to mice caused the protein’s accumulation in their brains, suggesting the same could have occurred in humans given the therapy.
Microglia Remember Bouts of Bodily Inflammation in Mice
Ashley Yeager | Apr 11, 2018
A new study reports that immune memory may contribute to neurodegenerative diseases.
Tau Production Increased in Alzheimer’s Patients
Jim Daley | Mar 21, 2018
The findings suggest that faster synthesis, rather than decreased clearance, causes the protein to build up in neurons.
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Catherine Offord | Feb 1, 2018
The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.
Do Microbes Trigger Alzheimer’s Disease?
Jill U. Adams | Sep 1, 2017
The once fringe idea is gaining traction among the scientific community.
Toward Treating Alzheimer’s Disease with Brain Waves
Ashley P. Taylor | Dec 7, 2016
In a mouse model, researchers mitigated three Alzheimer’s disease–associated symptoms by stimulating gamma waves with light.
More Evidence of Alzheimer’s Transmission
Jef Akst | Jan 27, 2016
Examining the brains of seven patients who died of the prion disease called Creutzfeldt–Jakob, researchers find signs of Alzheimer’s pathology. 
Delayed Turnover
Amanda B. Keener | Jul 21, 2015
Aggregate-forming amyloid β proteins are replenished more slowly with age, and this may contribute to a person's risk of developing Alzheimer’s disease.
Shoring Up Golgi To Slow Alzheimer’s
Kerry Grens | Dec 8, 2014
Blocking activity of a kinase in a mouse model protects Golgi in cells and reduces the build-up of amyloid β, a primary component of Alzheimer’s disease.
Week in Review: May 12–16
Tracy Vence | May 16, 2014
Antidepressant could prevent Alzheimer’s plaques; 12,000-year-old human skeleton sequenced; disentangling the mystery of octopus arms; taking a look at the ocular microbiome
Autophagy’s Role in Alzheimer’s
Abby Olena | Oct 3, 2013
Researchers show that amyloid beta is secreted from neurons in an autophagy-dependent manner.