APOE

Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.

Two copies of the APOE4 variant, which confers a higher risk of dementia, doubles the risk of severe symptoms as a result of infection with SARS-CoV-2, according to a study.

A growing body of evidence supports the theory that neural hyperactivity and hyperconnectivity precede the pathological changes that lead to neurodegeneration.

One variant limited the brain’s ability to use glucose.

Genetic variants in Alzheimer’s- and smoking-related genes appear to be under selection pressure, according to a study comparing the genomes of old and young participants.

Allen Roses, a professor of neurobiology at Duke University School of Medicine, has passed away at age 73.