Illustration of two weaving proteins
Fusion with Spider Silk Increases Anticancer Protein’s Stability
Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.
Fusion with Spider Silk Increases Anticancer Protein’s Stability
Fusion with Spider Silk Increases Anticancer Protein’s Stability

Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.

Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.

apoptosis
A drawing of pseudostratified gut epithelial cells in the early intestines, cells in red and nucleus in purple.
Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut
Natalia Mesa | May 18, 2022
Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.
line illustration of DNA with single-strand break
Cancer Cells Break Own DNA to Defend Against Radiation
Sophie Fessl | Apr 28, 2022
Self-inflicted DNA breaks let the cells hit pause on repair of radiation-induced DNA damage, giving them time to recover, an in vitro study shows.
Discover how to scale up cellular assays during drug discovery
High-Throughput Solutions for Lead Candidate Discovery
The Scientist Creative Services Team and Thermo Fisher Scientific
New technologies allow researchers to scale up assays for cellular functions.
Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
Diffuse star-like shapes with regions in purple, green, and both colors overlapped.
Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez | Mar 25, 2022
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
800x560-oct-5-2021
Technique Talk: Live-Cell Imaging Strategies to Quantify Phagocytosis
The Scientist Creative Services Team in collaboration with Sartorius
Discover how to image and quantitate phagocytosis in real time
Image of fruit fly epithelial cells (pseudo colored in this micrograph)
Epithelial Cell Signaling Helps Maintain Tissue Integrity
Annie Melchor | Nov 1, 2021
Using a transgenic fruit fly model, researchers demonstrate how epithelial barriers are maintained in living organisms despite high levels of cell turnover and death.
Infographic: Light Triggers Photocage Opening, Apoptosis Inhibition
Jef Akst | Jan 1, 2021
Researchers develop a caspase inhibitor that only works after being irradiated with UV light, giving them control over apoptosis in human cells.
Light-Activated Molecules Stop Apoptosis at the Flip of a Switch
Jef Akst | Jan 1, 2021
A new inhibitor gives researchers the ability to control programmed cell death in cultured human T cells.
Daniel Colón-Ramos Reveals the Mysteries of Worms’ Memories
Claudia Lopez-Lloreda | May 1, 2020
The Yale neuroscientist seeks to understand the brain’s architecture and function using C. elegans.
necroptosis apoptosis cancer t cell immunotherapy
Dying Cells Push the Mouse Immune System into Killing Tumors
Katarina Zimmer | Jun 21, 2019
Introducing either necroptotic cells or an enzyme that triggers necroptosis can wipe out cancer.
telomere length sticky stuck chromosome aging apoptosis cancer cell oxidative stress
Image of the Day: Sticky Telomeres
Chia-Yi Hou | May 16, 2019
Telomeres in cancer cells exposed to oxidative stress got shorter and stickier.
Image of the Day: Life and Death
Carolyn Wilke | Mar 22, 2019
When hair follicle stem cells lose their protein-based death cue, they take on a new role helping to repair wounds in skin.
The World Within
Bob Grant | Feb 1, 2019
Internalizing the environment might be the next step in humans’ relationship with our planet.
cell death infographic
Infographic: How Cells Cheat Death
Charles Q. Choi | Feb 1, 2019
Apoptosis and other types of programmed cell death appear to be reversible.
Cell Death Processes Are Reversible
Charles Q. Choi | Feb 1, 2019
Molecular programs can rescue cells already engaged in the process of apoptosis or other forms of programmed cell death.
John Sulston, Human Genome Project Leader, Dies
Kerry Grens | Mar 11, 2018
The biologist earned a Nobel Prize in 2002 for his work on C. elegans.
Image of the Day: Dial M for Murder
The Scientist Staff | Aug 16, 2017
M proteins from Streptococcus bacteria selectively kill mouse macrophages and human macrophage-like cells by prompting cell death.
Microglia Tamp Down Neurogenesis
Kerry Grens | Apr 7, 2016
The immune cells—known for clearing dead cells—also chew up live progenitors in neurogenic regions of mouse brains.