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3D illustration of p53 bound to DNA
One Protein to Rule Them All
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
One Protein to Rule Them All
One Protein to Rule Them All

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

apoptosis

A cell undergoing programmed cell death with internal components leaking out
Programmed Cell Death
The Scientist | Mar 4, 2024 | 1 min read
Multicellular organisms can self-destruct their cells through a variety of mechanisms.
Fluorescently labeled neuron cell bodies in blue in the center compartment of a three-compartment microfluidic chamber grow through tiny grooves to enter the left and the right chambers, where they extend axons fibers, also shown in blue.
Visualizing Axon Pruning
Tiffany Garbutt, PhD | Oct 2, 2023 | 2 min read
During development, neurons trim hundreds of excess axons in an intricately coordinated destructive process.
Cell division abstract image
Versatile and Sustainable: Cell Counting for the 21st Century
The Scientist and DeNovix Inc. | 3 min read
Discover how the latest cell counting technology is reshaping a mundane task for the future.
Infographic preview
Infographic: A Brain Implant Stops Tumor Growth in Rats
Holly Barker, PhD | Dec 12, 2022 | 1 min read
The new, implantable device converts ultrasound waves into electrical energy inside the brain, interfering with tumor cell division.
Render of cancer cells
Implantable Device Zaps Cancer Cells Using Electric Fields
Holly Barker, PhD | Dec 12, 2022 | 3 min read
A wireless brain implant inhibits tumor growth in rats, overcoming many design flaws of current devices used to treat glioblastoma.
Programmed Cell Death: Mechanisms for Cellular Self-Destruction
Programmed Cell Death Pathways
Elina Kadriu | 7 min read
Cells use a variety of programmed cell death mechanisms to maintain homeostasis through cellular self-destruction, including apoptosis, necroptosis, and pyroptosis.
A colored microscopy image showing cells that are dying in yellow and healthy cells in blue 
Sweet Taste Receptors Regulate Proteins in Developing Fruit Flies
Tess Joosse | Nov 14, 2022 | 2 min read
An unexpected find shows that sweet-sensing receptors also help epithelial cells in Drosophila larvae stay alive amid proteotoxic stress.
Illustration of two weaving proteinsĀ 
Fusion with Spider Silk Increases Anticancer Protein’s Stability
Dan Robitzski | Jul 5, 2022 | 2 min read
Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.
Discover how to scale up cellular assays during drug discovery
High-Throughput Solutions for Lead Candidate Discovery
The Scientist and Thermo Fisher Scientific | 1 min read
New technologies allow researchers to scale up assays for cellular functions.
A drawing of pseudostratified gut epithelial cells in the early intestines, cells in red and nucleus in purple.
Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut
Natalia Mesa, PhD | May 18, 2022 | 6 min read
Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.
line illustration of DNA with single-strand break
Cancer Cells Break Own DNA to Defend Against Radiation
Sophie Fessl, PhD | Apr 28, 2022 | 3 min read
Self-inflicted DNA breaks let the cells hit pause on repair of radiation-induced DNA damage, giving them time to recover, an in vitro study shows.
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Technique Talk: Live-Cell Imaging Strategies to Quantify Phagocytosis
The Scientist Creative Services Team in collaboration with Sartorius | 1 min read
Discover how to image and quantitate phagocytosis in real time
Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022 | 4 min read
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
Diffuse star-like shapes with regions in purple, green, and both colors overlapped.
Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez, PhD | Mar 25, 2022 | 5 min read
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
Image of fruit fly epithelial cells (pseudo colored in this micrograph)
Epithelial Cell Signaling Helps Maintain Tissue Integrity
Annie Melchor | Nov 1, 2021 | 2 min read
Using a transgenic fruit fly model, researchers demonstrate how epithelial barriers are maintained in living organisms despite high levels of cell turnover and death.
Infographic: Light Triggers Photocage Opening, Apoptosis Inhibition
Jef Akst | Jan 1, 2021 | 1 min read
Researchers develop a caspase inhibitor that only works after being irradiated with UV light, giving them control over apoptosis in human cells.
Light-Activated Molecules Stop Apoptosis at the Flip of a Switch
Jef Akst | Jan 1, 2021 | 3 min read
A new inhibitor gives researchers the ability to control programmed cell death in cultured human T cells.
Daniel Colón-Ramos Reveals the Mysteries of Worms’ Memories
Claudia Lopez-Lloreda, PhD | May 1, 2020 | 3 min read
The Yale neuroscientist seeks to understand the brain’s architecture and function using C. elegans.
necroptosis apoptosis cancer t cell immunotherapy
Dying Cells Push the Mouse Immune System into Killing Tumors
Katarina Zimmer | Jun 21, 2019 | 4 min read
Introducing either necroptotic cells or an enzyme that triggers necroptosis can wipe out cancer.
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