Image of fruit fly epithelial cells (pseudo colored in this micrograph)
Epithelial Cell Signaling Helps Maintain Tissue Integrity
Using a transgenic fruit fly model, researchers demonstrate how epithelial barriers are maintained in living organisms despite high levels of cell turnover and death.
ABOVE: Romain Levayer
Epithelial Cell Signaling Helps Maintain Tissue Integrity
Epithelial Cell Signaling Helps Maintain Tissue Integrity

Using a transgenic fruit fly model, researchers demonstrate how epithelial barriers are maintained in living organisms despite high levels of cell turnover and death.

Using a transgenic fruit fly model, researchers demonstrate how epithelial barriers are maintained in living organisms despite high levels of cell turnover and death.

ABOVE: Romain Levayer
apoptosis
Infographic: Light Triggers Photocage Opening, Apoptosis Inhibition
Jef Akst | Jan 1, 2021
Researchers develop a caspase inhibitor that only works after being irradiated with UV light, giving them control over apoptosis in human cells.
Light-Activated Molecules Stop Apoptosis at the Flip of a Switch
Jef Akst | Jan 1, 2021
A new inhibitor gives researchers the ability to control programmed cell death in cultured human T cells.
Daniel Colón-Ramos Reveals the Mysteries of Worms’ Memories
Claudia Lopez-Lloreda | May 1, 2020
The Yale neuroscientist seeks to understand the brain’s architecture and function using C. elegans.
necroptosis apoptosis cancer t cell immunotherapy
Dying Cells Push the Mouse Immune System into Killing Tumors
Katarina Zimmer | Jun 21, 2019
Introducing either necroptotic cells or an enzyme that triggers necroptosis can wipe out cancer.
telomere length sticky stuck chromosome aging apoptosis cancer cell oxidative stress
Image of the Day: Sticky Telomeres
Chia-Yi Hou | May 16, 2019
Telomeres in cancer cells exposed to oxidative stress got shorter and stickier.
Image of the Day: Life and Death
Carolyn Wilke | Mar 22, 2019
When hair follicle stem cells lose their protein-based death cue, they take on a new role helping to repair wounds in skin.
The World Within
Bob Grant | Feb 1, 2019
Internalizing the environment might be the next step in humans’ relationship with our planet.
cell death infographic
Infographic: How Cells Cheat Death
Charles Q. Choi | Feb 1, 2019
Apoptosis and other types of programmed cell death appear to be reversible.
Cell Death Processes Are Reversible
Charles Q. Choi | Feb 1, 2019
Molecular programs can rescue cells already engaged in the process of apoptosis or other forms of programmed cell death.
John Sulston, Human Genome Project Leader, Dies
Kerry Grens | Mar 11, 2018
The biologist earned a Nobel Prize in 2002 for his work on C. elegans.
Image of the Day: Dial M for Murder
The Scientist Staff | Aug 16, 2017
M proteins from Streptococcus bacteria selectively kill mouse macrophages and human macrophage-like cells by prompting cell death.
Microglia Tamp Down Neurogenesis
Kerry Grens | Apr 7, 2016
The immune cells—known for clearing dead cells—also chew up live progenitors in neurogenic regions of mouse brains. 
Mitochondria Exchange
Amanda B. Keener | Aug 26, 2015
A decade of research on intercellular mitochondrial transfer has answered some long-standing questions and raised new ones.
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Book Excerpt from p53
Sue Armstrong | Mar 31, 2015
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.
Protein Helps Cells Adapt—or Die
Ruth Williams | Jul 3, 2014
Scientists show how cell stress both prevents and promotes cell suicide in a study that’s equally divisive.