Infographic showing how neurodegenerative diseases have long been associated with aggregations of apparently toxic proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

beta-amyloid
Amyloid plaques on axons of neurons
The Misunderstood Proteins of Neurodegeneration
Catherine Offord | Aug 1, 2022
The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.
a patient getting blood drawn for testing
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Poor Sleep Linked with Future Amyloid-β Build Up
Abby Olena | Sep 11, 2020
Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.
Alzheimer’s-Related Protein Can Spread by Tainted Growth Hormone
Carolyn Wilke | Dec 14, 2018
A hormone treatment contaminated with amyloid-β given to mice caused the protein’s accumulation in their brains, suggesting the same could have occurred in humans given the therapy.
Amyloid plaques (stained for amyloid-? peptide) detected in a post-mortem brain sample of a patient with Alzheimer's disease. Purple purple dots in the background are the nuclei of neurons and glia.
Herpes Viruses Implicated in Alzheimer’s Disease
Anna Azvolinsky | Jun 21, 2018

A new study shows that the brains of Alzheimer’s disease patients have a greater viral load, while another study in mice shows infection leads to amyloid-β build up.

Alzheimer’s Should be Characterized by Biomarkers: Report
Diana Kwon | Apr 10, 2018
A proposed definition of the disease emphasizes signs of neurodegeneration and the presence of β-amyloid and tau, rather than cognitive symptoms.
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Catherine Offord | Feb 1, 2018
The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.
Do Microbes Trigger Alzheimer’s Disease?
Jill U. Adams | Sep 1, 2017
The once fringe idea is gaining traction among the scientific community.
Infographic: Brain Infection and Alzheimer’s Disease Pathology
Jill U. Adams | Aug 31, 2017
Emerging evidence links bacterial or viral infection with the neuropathology of Alzheimer’s disease.
More Evidence of Alzheimer’s Transmission
Jef Akst | Jan 27, 2016
Examining the brains of seven patients who died of the prion disease called Creutzfeldt–Jakob, researchers find signs of Alzheimer’s pathology. 
Delayed Turnover
Amanda B. Keener | Jul 21, 2015
Aggregate-forming amyloid β proteins are replenished more slowly with age, and this may contribute to a person's risk of developing Alzheimer’s disease.
Tangle Trigger
Jyoti Madhusoodanan | Jan 1, 2015
An enzyme that cleaves tau protein in acidic cellular conditions may trigger early events in Alzheimer’s disease.
Shoring Up Golgi To Slow Alzheimer’s
Kerry Grens | Dec 8, 2014
Blocking activity of a kinase in a mouse model protects Golgi in cells and reduces the build-up of amyloid β, a primary component of Alzheimer’s disease.
In Old Blood
Jef Akst | Aug 1, 2014
The body of a supercentenarian expands science’s appreciation for the physiological limits of aging.
Aged Wisdom
Jef Akst | Jul 31, 2014
Supercentenarian Hendrikje van Andel-Schipper appeared on CNN in 2009, before donating her body to science and yielding insights into her remarkable longevity.