beta-amyloid

The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.

The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.

Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.

Two rodent models of glaucoma have defects in the waste drainage system.

A hormone treatment contaminated with amyloid-β given to mice caused the protein’s accumulation in their brains, suggesting the same could have occurred in humans given the therapy.

A proposed definition of the disease emphasizes signs of neurodegeneration and the presence of β-amyloid and tau, rather than cognitive symptoms.

The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.

The once fringe idea is gaining traction among the scientific community.

Emerging evidence links bacterial or viral infection with the neuropathology of Alzheimer’s disease.

Examining the brains of seven patients who died of the prion disease called Creutzfeldt–Jakob, researchers find signs of Alzheimer’s pathology. 

Aggregate-forming amyloid β proteins are replenished more slowly with age, and this may contribute to a person's risk of developing Alzheimer’s disease.

An enzyme that cleaves tau protein in acidic cellular conditions may trigger early events in Alzheimer’s disease.

Blocking activity of a kinase in a mouse model protects Golgi in cells and reduces the build-up of amyloid β, a primary component of Alzheimer’s disease.

The body of a supercentenarian expands science’s appreciation for the physiological limits of aging.

Supercentenarian Hendrikje van Andel-Schipper appeared on CNN in 2009, before donating her body to science and yielding insights into her remarkable longevity.