Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Participant’s Diagnosis Halts Gene Therapy Clinical Trial

The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.

The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.

clinical data
Fecal Microbiota Transplantation Is Poised for a Makeover
Fecal Microbiota Transplantation Is Poised for a Makeover
Shawna Williams | Jun 1, 2021
With multiple microbiota therapeutics in the pipeline for recurrent Clostridium difficile infection, clinicians foresee a shift in treatment options for the condition.
Severe Symptoms of MIS-C Typically Clear Within Six Months: Study
Severe Symptoms of MIS-C Typically Clear Within Six Months: Study
Catherine Offord | May 26, 2021
Some children who experience the severe inflammatory condition after COVID-19 may continue to experience milder problems such as muscle weakness or anxiety even after that period, according to a small observational study in the UK.
Blood Biomarkers Predict the Onset of Labor: Study
Blood Biomarkers Predict the Onset of Labor: Study
Abby Olena | May 6, 2021
Researchers integrated information from 45 protein, metabolite, and immune data points to identify a window two to four weeks before a pregnant person will go into labor.
Pandemic Accelerates Trend Toward Remote Clinical Trials
Pandemic Accelerates Trend Toward Remote Clinical Trials
Jef Akst | May 1, 2021
Now more than ever before, recruiting patients for a research study doesn’t have to mean getting them to leave their homes.
EXCLUSIVE
Frontiers Pulls Special COVID-19 Issue After Content Dispute
Frontiers Pulls Special COVID-19 Issue After Content Dispute
Catherine Offord | Apr 28, 2021
The issue’s guest editors resign after falling out with the publisher over the management of papers, including a rejected manuscript on ivermectin, that were submitted for a special issue on drug repurposing for COVID-19.
New Malaria Vaccine Shows Most Efficacy of Any to Date: Small Trial
New Malaria Vaccine Shows Most Efficacy of Any to Date: Small Trial
Catherine Offord | Apr 26, 2021
Immunization had up to 77 percent efficacy in a Phase 2 clinical study of 450 children in Burkina Faso.
Frontiers Removes Controversial Ivermectin Paper Pre-Publication
Frontiers Removes Controversial Ivermectin Paper Pre-Publication
Catherine Offord | Mar 2, 2021
A review article containing contested claims about the tropical medicine drug as a COVID-19 treatment was listed as “provisionally accepted” on the journal’s website before being removed this week.
Gene Therapy in One Eye Improves Vision in Both Eyes
Gene Therapy in One Eye Improves Vision in Both Eyes
Abby Olena | Dec 11, 2020
It’s not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.
Eli Lilly Halts Antibody Trial in Hospitalized COVID-19 Patients
Eli Lilly Halts Antibody Trial in Hospitalized COVID-19 Patients
Ashley Yeager | Oct 27, 2020
Recent data show that the drug bamlanivimab, also known as LY-CoV555, does not appear to help those with severe cases of COVID-19, but trials continue for milder cases.
Steroid Drugs Are an Effective Treatment for Severe COVID-19: WHO
Steroid Drugs Are an Effective Treatment for Severe COVID-19: WHO
Catherine Offord | Sep 3, 2020
A meta-analysis of seven randomized controlled trials concludes that dexamethasone and other corticosteroids reduce 28-day mortality in seriously ill patients.
Toward COVID-19 Testing Any Time, Anywhere
Toward COVID-19 Testing Any Time, Anywhere
Abby Olena | Sep 2, 2020
Researchers are adapting CRISPR, synthetic biology, and other creative approaches to detect SARS-CoV-2 nucleic acids outside of the lab or doctors’ offices, in the hopes of making diagnostics more affordable and accessible.
Trials Seek to Answer if Vitamin D Could Help in COVID-19
Trials Seek to Answer if Vitamin D Could Help in COVID-19
Abby Olena | Aug 12, 2020
In clinical studies worldwide, researchers are testing the possibility that supplements of the vitamin could prevent or decrease the severity of SARS-CoV-2 infections.
Insight into Dexamethasone’s Benefits in Severe COVID-19
Insight into Dexamethasone’s Benefits in Severe COVID-19
Abby Olena | Jun 19, 2020
The steroid’s exceptional performance in early results from the RECOVERY clinical trial in the United Kingdom is a rational outcome of the drug’s anti-inflammatory effects, experts say.
Special Report
Surgisphere Sows Confusion About Another Unproven COVID-19 Drug
Surgisphere Sows Confusion About Another Unproven COVID-19 Drug
Catherine Offord | Jun 16, 2020
The company behind a now-discredited study on hydroxychloroquine also posted a report that has been cited by Latin American governments recommending ivermectin as a possible coronavirus treatment. Clinicians there say the effects have been extremely damaging.
Surgisphere Fallout Hits African Nonprofit’s COVID-19 Efforts
Surgisphere Fallout Hits African Nonprofit’s COVID-19 Efforts
Catherine Offord | Jun 7, 2020
The company had helped develop a tool to aid decision-making in distributing limited medical equipment among coronavirus patients, but two high-profile retractions call into question the validity of Surgisphere’s work in toto.
<em>Lancet, NEJM </em>Retract Surgisphere Studies on COVID-19 Patients
Lancet, NEJM Retract Surgisphere Studies on COVID-19 Patients
Catherine Offord | Jun 4, 2020
All authors other than company founder and CEO Sapan Desai were “unable to complete an independent audit of the data,” The Lancet states.
Concerns Build Over Surgisphere&rsquo;s COVID-19 Dataset
Concerns Build Over Surgisphere’s COVID-19 Dataset
Catherine Offord | Jun 2, 2020
NEJM and The Lancet issue expressions of concern as researchers question where the company got its data on thousands of coronavirus patients.
Exclusive
Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere
Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere
Catherine Offord | May 30, 2020
Scientists have raised questions about the dataset published in The Lancet last week that triggered the suspension of clinical trials around the world—and about Surgisphere Corporation, the company behind the study.
A New Way to Establish Cause and Effect in Epidemiology?
A New Way to Establish Cause and Effect in Epidemiology?
Rachael Moeller Gorman | Jan 1, 2020
A technique called Mendelian randomization is overturning the conclusions of observational studies in public health. But researchers question whether the method can overcome its fundamental limitations.