Open orange pill bottle with rounded white pills
What’s the Evidence for Fluvoxamine in COVID-19? 
The US FDA’s decision not to grant an emergency use authorization for the antidepressant as a COVID-19 treatment highlights a lack of consensus among researchers about how to interpret clinical data on the drug.
ABOVE: © iStock.com, AndrewSoundarajan
What’s the Evidence for Fluvoxamine in COVID-19? 
What’s the Evidence for Fluvoxamine in COVID-19? 

The US FDA’s decision not to grant an emergency use authorization for the antidepressant as a COVID-19 treatment highlights a lack of consensus among researchers about how to interpret clinical data on the drug.

The US FDA’s decision not to grant an emergency use authorization for the antidepressant as a COVID-19 treatment highlights a lack of consensus among researchers about how to interpret clinical data on the drug.

ABOVE: © iStock.com, AndrewSoundarajan

clinical data

Bacteria on the skin
Biotech Tries Manipulating the Skin Microbiome
Bianca Nogrady | Apr 18, 2022
Researchers are revealing the complexity of the microbial community living on the body—and paving the way for new bacteria-targeting treatments for acne and other dermatological conditions.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Doctor holding stethoscope in front of European Union flag
New EU Protocol Aims to Improve Clinical Trial Transparency
Sophie Fessl | Feb 16, 2022
A new regulation and registry covering investigational medicinal products mandates reporting and supports multinational trials.
building sign
Johnson & Johnson Vaccine Garners First Full Approval
Chloe Tenn | Nov 24, 2021
Health Canada has given the single COVID-19 shot the official greenlight for use in people 18 and older.
blue and white building sign
Biden Picks Robert Califf to Head the FDA for a Second Time
Chloe Tenn | Nov 12, 2021
The cardiologist was briefly the FDA Commissioner in the Obama Administration, and now has a second chance to act on plans he tried to implement during his first tenure.
Molecular structure of fluvoxamine
A Closer Look at the New Fluvoxamine Trial Data
Catherine Offord | Nov 2, 2021
Authors of a newly published study on the use of an antidepressant for COVID-19 claim the drug greatly reduces hospitalizations and mortality. But some experts question whether that’s really what the data show.
An artistic rendering of blue neurons against a white background
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
A person wearing a purple glove holds out a blue pill
Fecal Microbiota Transplantation Is Poised for a Makeover
Shawna Williams | Jun 1, 2021
With multiple microbiota therapeutics in the pipeline for recurrent Clostridium difficile infection, clinicians foresee a shift in treatment options for the condition.
A hospital corridor with empty gurney
Severe Symptoms of MIS-C Typically Clear Within Six Months: Study
Catherine Offord | May 26, 2021
Some children who experience the severe inflammatory condition after COVID-19 may continue to experience milder problems such as muscle weakness or anxiety even after that period, according to a small observational study in the UK.
A pregnant figure is shaded in blue and outlined in blue, pink, and purple
Blood Biomarkers Predict the Onset of Labor: Study
Abby Olena | May 6, 2021
Researchers integrated information from 45 protein, metabolite, and immune data points to identify a window two to four weeks before a pregnant person will go into labor.
Pandemic Accelerates Trend Toward Remote Clinical Trials
Jef Akst | May 1, 2021
Now more than ever before, recruiting patients for a research study doesn’t have to mean getting them to leave their homes.
EXCLUSIVE
Assorted pills and tablets
Frontiers Pulls Special COVID-19 Issue After Content Dispute
Catherine Offord | Apr 28, 2021
The issue’s guest editors resign after falling out with the publisher over the management of papers, including a rejected manuscript on ivermectin, that were submitted for a special issue on drug repurposing for COVID-19.
New Malaria Vaccine Shows Most Efficacy of Any to Date: Small Trial
Catherine Offord | Apr 26, 2021
Immunization had up to 77 percent efficacy in a Phase 2 clinical study of 450 children in Burkina Faso.
Frontiers Removes Controversial Ivermectin Paper Pre-Publication
Catherine Offord | Mar 2, 2021
A review article containing contested claims about the tropical medicine drug as a COVID-19 treatment was listed as “provisionally accepted” on the journal’s website before being removed this week.
Gene Therapy in One Eye Improves Vision in Both Eyes
Abby Olena | Dec 11, 2020
It’s not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.
Eli Lilly Halts Antibody Trial in Hospitalized COVID-19 Patients
Ashley Yeager | Oct 27, 2020
Recent data show that the drug bamlanivimab, also known as LY-CoV555, does not appear to help those with severe cases of COVID-19, but trials continue for milder cases.
Steroid Drugs Are an Effective Treatment for Severe COVID-19: WHO
Catherine Offord | Sep 3, 2020
A meta-analysis of seven randomized controlled trials concludes that dexamethasone and other corticosteroids reduce 28-day mortality in seriously ill patients.
Toward COVID-19 Testing Any Time, Anywhere
Abby Olena | Sep 2, 2020
Researchers are adapting CRISPR, synthetic biology, and other creative approaches to detect SARS-CoV-2 nucleic acids outside of the lab or doctors’ offices, in the hopes of making diagnostics more affordable and accessible.
Trials Seek to Answer if Vitamin D Could Help in COVID-19
Abby Olena | Aug 12, 2020
In clinical studies worldwide, researchers are testing the possibility that supplements of the vitamin could prevent or decrease the severity of SARS-CoV-2 infections.