Colorectal tumor cells limit their DNA repair in response to a targeted therapy, giving them a greater chance to develop resistance to the drug.

Some experts blame our modern, sugary diet, while others think that gut microbiome changes and sedentary lifestyles may play a role. Altogether, the causes are far from clear.

Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.

Sensors encapsulated with oral chemotherapy drugs help patients and physicians keep track of treatments.

The Creighton University researcher discovered the genetic basis of hereditary breast-ovarian cancer syndrome.

Better treatment and diagnoses have helped more people survive, but economic disparities in outcomes for some preventable cancers have gotten worse.

The treatment also curbed the growth of nearby metastases that did not receive the drug.

The bacteria also promoted the growth of human colon cancer cells in a dish.

By implanting patient- or rodent-derived mini-guts into mice, scientists can rapidly create more-accurate murine models of the disease

A cell phone–based microscope can identify mutations in tumor tissue and image products of DNA sequencing reactions.

Member, Department of Immunology, St. Jude Children’s Research Hospital. Age: 43

An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.

A long noncoding RNA associated with DNA methylation has the power to regulate colon cancer growth in vitro.

From the tissue of numerous colon cancer patients, researchers build 3-D cultures of tumors.

Nanoparticle-producing bacteria may simplify the diagnosis of cancer and other medical conditions.

Study finds that prediagnosis obesity is predictive of poor prognosis, even among patients who have a molecular marker associated with better disease outcome.

The development of serrated polyps depends on bacteria present in the gut, a mouse study shows.  

Researchers develop a strategy for rendering a toxic drug harmless—until it encounters a pair of enzymes that signals cancer cells are nearby.

Contrary to existing dogma, colon cancer cell mitochondria carry fewer mutations than mitochondria of normal body cells.