Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Internal Clock Disruptions Increase Colon Cancer Risk in Mice

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

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Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez | Mar 25, 2022 | 5 min read
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
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Bacteria Set Off Viral “Bombs” Inside Neighbors
Natalia Mesa | Mar 7, 2022 | 2 min read
A study finds some E. coli can deploy a chemical called colibactin to reawaken long-dormant viruses inside bacteria, causing destruction.
Engineered Bacteria Make Tumors More T Cell-Friendly
Engineered Bacteria Make Tumors More T Cell-Friendly
Aparna Nathan | 5 min read
Microbes designed to produce specific immunomodulatory metabolites could give immunotherapy a boost.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa | Feb 3, 2022 | 5 min read
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
Colon Cancer Uses a Regenerative Playbook to Metastasize
Shawna Williams | Apr 1, 2020 | 5+ min read
A study finds similarities between cells that heal wounds and those that lead deadly cancerous invasions.
Cancer Cells Increase DNA Mutations to Evade Treatment
Abby Olena | Nov 7, 2019 | 3 min read
Colorectal tumor cells limit their DNA repair in response to a targeted therapy, giving them a greater chance to develop resistance to the drug.
polyp colorectal cancer
There’s a Troubling Rise in Colorectal Cancer Among Young Adults
Katarina Zimmer | Aug 26, 2019 | 5+ min read
Some experts blame our modern, sugary diet, while others think that gut microbiome changes and sedentary lifestyles may play a role. Altogether, the causes are far from clear.
Exercise Changes Our Gut Microbes, But How Isn’t Yet Clear
Ashley Yeager | Aug 15, 2019 | 5 min read
Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.
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Smart Pills Help Monitor Cancer Patients’ Therapy
Chia-Yi Hou | Jul 15, 2019 | 5 min read
Sensors encapsulated with oral chemotherapy drugs help patients and physicians keep track of treatments.
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Henry Lynch, Leader in Cancer Genetics, Dies
Chia-Yi Hou | Jun 7, 2019 | 2 min read
The Creighton University researcher discovered the genetic basis of hereditary breast-ovarian cancer syndrome.
US Cancer Death Rate Dropped for 25 Years Starting in 1991
Carolyn Wilke | Jan 9, 2019 | 1 min read
Better treatment and diagnoses have helped more people survive, but economic disparities in outcomes for some preventable cancers have gotten worse.
Locally-Injected Immunotherapy Eradicates Tumors in Mice
Diana Kwon | Feb 1, 2018 | 2 min read
The treatment also curbed the growth of nearby metastases that did not receive the drug.
Streptococcus gallolyticus Spurs Colorectal Tumor Growth in Mice
Diana Kwon | Jul 14, 2017 | 2 min read
The bacteria also promoted the growth of human colon cancer cells in a dish.
Gut Organoid Transplants Produce Colorectal Cancer in Mice
Diana Kwon | Apr 30, 2017 | 3 min read
By implanting patient- or rodent-derived mini-guts into mice, scientists can rapidly create more-accurate murine models of the disease
Next Generation: Mobile Microscope Detects DNA Sequences
Abby Olena | Jan 17, 2017 | 3 min read
A cell phone–based microscope can identify mutations in tumor tissue and image products of DNA sequencing reactions.
Thirumala-Devi Kanneganti: Immersed in Immunology
Karen Zusi | Jun 1, 2016 | 3 min read
Member, Department of Immunology, St. Jude Children’s Research Hospital. Age: 43
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 5+ min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Managing Methylation
Karen Zusi | Jan 1, 2016 | 2 min read
A long noncoding RNA associated with DNA methylation has the power to regulate colon cancer growth in vitro.
Organoid Biobank
Kerry Grens | May 11, 2015 | 2 min read
From the tissue of numerous colon cancer patients, researchers build 3-D cultures of tumors.