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An image of cells with the center stained green and some cells stained magenta over a black background.
Growing Milk-Secreting Mammary Organoids
Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer.
Growing Milk-Secreting Mammary Organoids
Growing Milk-Secreting Mammary Organoids

Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer.

Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer.

embryonic stem cells

Image of an embryo built from Lego bricks showing cell populations in green and red.
Stem Cell-Based Embryo Models Add a Dimension to Developmental Biology
Shelby Bradford, PhD | Sep 13, 2024 | 10+ min read
Studying human embryonic development is complicated for several reasons. Models derived from pluripotent stem cells representing distinct stages offer a path to studying this process.
Embryoid bodies, at the top of the page, are a cluster of embryonic stem cells (ESCs) that differentiate portions into ectoderm (orange), mesoderm (dark blue), and endoderm (pink).
Infographic: The Many Paths to Stem Cell-Based Embryo Models
Shelby Bradford, PhD | Sep 13, 2024 | 5 min read
Culturing pluripotent stem cells to replicate different stages of embryonic development allows researchers to more easily investigate this period.
Promoting Stem Cell Growth and Self-Renewal In Vitro
The Scientist Creative Services Team in collaboration with MilliporeSigma | 2 min read
An engineered laminin substrate facilitates high-quality human stem cell cultures.
A microscopy image of stem cells
An Ode to Stem Cells
Meenakshi Prabhune, PhD | Sep 13, 2024 | 3 min read
Leveraging the versatility of stem cells allows researchers to advance science across multiple disciplines.
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Karyotype with most chromosomes in blue, one in red and green. 
Researchers Fuse Mouse Chromosomes in Scientific First
Natalia Mesa, PhD | Aug 25, 2022 | 4 min read
The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.
microscope image series showing synthetic embryo development
Mouse Embryo: No Sperm, Egg, or Uterus Required
Christie Wilcox, PhD | Aug 2, 2022 | 3 min read
Using stem cells and a bioreactor, researchers generated living embryos that survived for more than a week and began to develop internal organs.
Human Blastocyst-Like Structures Made in the Lab
Abby Olena, PhD | Mar 17, 2021 | 4 min read
Two new papers describe the generation of so-called blastoids, which could avoid the use of embryonic cells and make studying early human development much more accessible.
Most Members of Federal Fetal Tissue Ethics Panel Oppose Abortion
Lisa Winter | Aug 3, 2020 | 3 min read
The members of a new advisory board to the NIH met for the first time and will weigh in on federal funding for grants that rely on donated tissue from abortions.
fetal tissue research stem cells
Scientists Grapple with US Restrictions on Fetal Tissue Research
Diana Kwon | Mar 2, 2020 | 6 min read
The Trump administration’s changes to policy involving material donated from abortions have led scientists to adjust their research projects or seek alternative sources of funding.
esc embryonic stem cell fetal tissue
NIH Scientists Banned from Studying Human Fetal Tissue
Kerry Grens | Jun 6, 2019 | 2 min read
External researchers funded by US federal grants can continue their experiments under tighter scrutiny.
First Mouse Embryos Made from Two Fathers
Abby Olena, PhD | Oct 11, 2018 | 3 min read
The bipaternal pups died soon after birth, but mice with two mothers grew into fertile adults.
Mouse Stem Cells Made to Form Embryo-Like Structures
Ruth Williams | Oct 3, 2018 | 3 min read
With just a molecular nudge, aggregates of embryonic stem cells take shape as a “gastroloid,” bearing the genetic hallmarks and spatial organization of early development.
Cardiac Cell Transplants Help Monkeys’ Hearts
Ashley Yeager | Jul 2, 2018 | 2 min read
The organ’s blood-pumping capacity improved with the infusion of cells, a study shows.
Studies Show How Cells Differentiate at Life’s Beginning
Shawna Williams | Apr 27, 2018 | 1 min read
A trio of papers provide new insight into embryo development.
Image of the Day: Retinal Cell Implant
The Scientist and The Scientist Staff | Apr 17, 2018 | 1 min read
For the first time, a transplant of replacement tissue grown from stem cells has been shown to be feasible for patients with macular degeneration.
Researchers Argue for “Embryoid” Ethics Revamp
Bob Grant | Mar 22, 2017 | 2 min read
Scientists issue a call to reconsider the rules governing the creation of tissues, organs, and other structures made possible by recent advances in synthetic biology. 
Meet the First Artificial Embryo Made From Stem Cells
Bob Grant | Mar 2, 2017 | 2 min read
Researchers report growing a mouse embryo using two types of early stem cells.
Week in Review: October 17–21
Jef Akst | Oct 20, 2016 | 2 min read
Report finds that pathologist involved in anonymous defamation case committed multiple acts of misconduct; growing eggs from stem cells; neutrophils’ role in metastasis; convergent evolution in birds
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