exosomes

Scientists choose ultracentrifugation techniques for simplicity and proven efficacy in exosome purification.

The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

Taylor, formerly of the University of Louisville, is known for his discovery of and research on tumor-secreted exosomes.  

Mice that received the stem cell–derived treatment were less frail compared with controls, a study reports.

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  

Explore why extracellular vesicles are attractive candidates for new therapeutic approaches.

3-D cell culture recapitulates in vivo environments for generating physiologically relevant extracellular vesicles.

Vesicles containing fragments of the organelles released from stressed adipocytes protect the heart against oxygen deprivation, a study in mice shows.

Chris Heger and Johan Skog will discuss exosomes, some of the latest diagnostic applications in the exosome field, and introduce Simple Western technology. 

During bacterial infection, autophagy proteins appear to regulate the release of cell-saving exosomes, which bear the brunt of toxin damage.

Specialized exosomes sop up bacterial toxins, a study finds.

This year’s most beautiful illustrations covered topics including the molecular underpinnings of Parkinson’s disease and strategies for tracking marine organisms around the world’s oceans.

Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.

A small study finds that the tiny extracellular vesicles from patients with hepatocellular carcinoma have RNA content distinct from patients with cirrhosis only.

A growing branch of research on how plants use exosomes to interact with their environment is opening up a new field of plant biology.

Small RNA-containing particles in ginger root are found to promote the growth of beneficial bacteria and alleviate colitis in mouse guts.

Small microRNA-containing particles found in the plant can boost populations of healthy gut bacteria, and even improve colitis symptoms in mice.

A growing branch of research on how plants use exosomes to interact with their environment is opening up a new field of plant biology.

The vesicles promote metastasis after chemotherapy, but the authors say the results shouldn’t alarm patients and may point to ways to improve treatments.