A color-annotated image of the muscles in the whole body of a fruit fly.
| 3 min read
Molecular cartography helped scientists map mRNA localization in the muscles and brains of adult Drosophila.

fluorescence microscopy

Lenses of a fluorescent microscope illuminate a sample on a microscope slide.

A Colorful Approach to Tracking Cellular Cargo

Microscopic image of a live amoeba.

Illuminating Specimens Through Live Cell Imaging

Charting a New Course Through the Injured Brain

An image of neurons, astrocytes, and other glial cells acquired using fluorescence microscopy.

Troubleshooting Fluorescence Microscopy Experiments

Dream Big and Achieve Real-Time Single Cell Imaging Without Camera Limitations

Sort What You See

Illustration of newly discovered mechanism allowing kinesin to “walk” down a microtubule. A green kinesin molecule with an attached yellow fluorophore is shown passing through a blue laser as it rotates step by step along a red and purple microtubule, fueled by blue ATP molecules that are hydrolyzed into orange ADP and phosphate groups.

High-Resolution Microscope Watches Proteins Strut Their Stuff

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Microscopic image of nerves in the eye, a pathogen, and t cells

Science Snapshot: Eye Immunity

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Kirsty Wright is searching for evidence in a missing persons investigation. She is wearing a blue shirt and glasses. Behind her is dense vegetation and police procedural tape.

How a Forensic Biologist Exposed a DNA Lab Scandal That Shook Australia

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Hands holding an older woman’s hands.

One Gene Influences 75 Percent of Alzheimer’s Disease Cases

A picture of Rohita Roy, a postdoc at Stanford University.

Postdoc Portrait: Rohita Roy

Multimedia

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From Data to Discovery: Omics in Therapeutic Innovation

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Exploring Organoids for Disease Modeling Research

February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

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Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

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Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

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Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

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Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies