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Rendering of a light blue NLRP3 inflammasome against a black background
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice
In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice

In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.

In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.

inflammasomes
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Retrotransposon RNA Triggers NLRC4 Inflammasome Formation: Study
Rachael Moeller Gorman | Dec 10, 2021 | 4 min read
Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic elements.
close-up of a retina showing blood vessels and a damaged spot
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
Katarina Zimmer | Sep 29, 2021 | 5 min read
A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021 | 10+ min read
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
an explosion of red light radiating out from a core
Could Curbing Runaway Immune Responses Treat COVID-19?
Shawna Williams | Apr 21, 2020 | 5 min read
Drugs targeting patients’ immune systems, rather than the virus itself, could be key to recovery from severe cases of the disease, some researchers suggest.
Image of the Day: Dial M for Murder
The Scientist Staff | Aug 16, 2017 | 1 min read
M proteins from Streptococcus bacteria selectively kill mouse macrophages and human macrophage-like cells by prompting cell death.
Protein Clumps Spread Inflammation
Kate Yandell | Jun 22, 2014 | 4 min read
ASC specks—protein aggregations that drive inflammation—are released from dying immune cells, expanding the reach of a defense response.
Top 7 in Microbiology
Edyta Zielinska | Sep 26, 2011 | 3 min read
A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000
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