The discovery of gene variants in cases of hereditary spastic dysplasia could provide a diagnosis to affected families where no genetic cause could be found before.

Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.

The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.

Far from being inert fat-storage depots within cells, these lipid-loaded organelles recruit immune proteins and block bacterial growth.

Wakelam, who died of a suspected COVID-19 infection, is remembered for his research on the physiological function of lipids.

The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.

A single-celled organism has an energy-producing enzyme with unique features.

From 500-million-year-old fat to a newly discovered virus, here are some stunners from The Scientist in 2018.

Low levels of a biochemical process involved in fat breakdown predicts weight gain and metabolic complications more than a decade later.

Insulin resistance and high levels of insulin and lipids all precede the development of metabolic dysfunction. Which metabolic factor is to blame?

Lipids and insulin play important roles in blood sugar regulation, and altered levels of either could kick start metabolic dysfunction.

A new experimental system demonstrates that precursors of ribonucleotides, amino acids, and lipids may have simultaneously arisen from the same prebiotic chemistry.

Male scientists stress mice out; using SCNT to reprogram adult cells; acetate can reach mouse brain, reduce appetite; WHO sounds “post-antibiotic era” alarm

Researchers report the first evidence of cryopreservation by an overwintering insect in which stores of an uncommon lipid are critical.

Shared sequences within the brain lipid-metabolism pathway between Neanderthals and modern Europeans highlight questions about how these genetic similarities arose.

The timing of meals affects the levels of lipids in the livers of mice, according to a study.

Human variations in a gene that causes matted fur in mutant mice are tied to the skin malady.

There are five steps of autophagosome biogenesis: induction, expansion, vesicle completion, fusion, and cargo degradation.