Human Protein Dissolves Bacterial Membranes
Human Protein Dissolves Bacterial Membranes
The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.
Human Protein Dissolves Bacterial Membranes
Human Protein Dissolves Bacterial Membranes

The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.

The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.

lipid
The Community-Wide Effort to Standardize QA/QC for Metabolomics and Lipidomics
The Community-Wide Effort to Standardize QA/QC for Metabolomics and Lipidomics
The Scientist Creative Services Team | Apr 27, 2021
Perspectives on the basics and future of QA/QC
Lipid Droplets Are Intracellular Bacteria-Fighting Machines
Lipid Droplets Are Intracellular Bacteria-Fighting Machines
Ruth Williams | Oct 15, 2020
Far from being inert fat-storage depots within cells, these lipid-loaded organelles recruit immune proteins and block bacterial growth.
Lipid Expert and Babraham Institute Director Michael Wakelam Dies
Lipid Expert and Babraham Institute Director Michael Wakelam Dies
Amy Schleunes | Apr 7, 2020
Wakelam, who died of a suspected COVID-19 infection, is remembered for his research on the physiological function of lipids.
Immunology Leader Vincenzo Cerundolo Dies
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
Image of the Day: Unusual ATP Synthase
Image of the Day: Unusual ATP Synthase
Emily Makowski | Jan 8, 2020
A single-celled organism has an energy-producing enzyme with unique features.
Photos of the Year
Photos of the Year
Carolyn Wilke | Dec 21, 2018
From 500-million-year-old fat to a newly discovered virus, here are some stunners from The Scientist in 2018.
Researchers Identify Biomarkers for Obesity Risk in Women
Researchers Identify Biomarkers for Obesity Risk in Women
Catherine Offord | May 31, 2018
Low levels of a biochemical process involved in fat breakdown predicts weight gain and metabolic complications more than a decade later.
What Causes Type 2 Diabetes?
What Causes Type 2 Diabetes?
Barbara E. Corkey | Jul 1, 2016
Insulin resistance and high levels of insulin and lipids all precede the development of metabolic dysfunction. Which metabolic factor is to blame?
How High Fat and Insulin Levels May Lead to Diabetes
How High Fat and Insulin Levels May Lead to Diabetes
Barbara E. Corkey | Jun 30, 2016
Lipids and insulin play important roles in blood sugar regulation, and altered levels of either could kick start metabolic dysfunction.
On the Origins of Life
On the Origins of Life
Jef Akst | Mar 17, 2015
A new experimental system demonstrates that precursors of ribonucleotides, amino acids, and lipids may have simultaneously arisen from the same prebiotic chemistry.
Week in Review: April 28–May 2
Week in Review: April 28–May 2
Tracy Vence | May 2, 2014
Male scientists stress mice out; using SCNT to reprogram adult cells; acetate can reach mouse brain, reduce appetite; WHO sounds “post-antibiotic era” alarm
Rare Fat Keeps Fly from Freezing
Rare Fat Keeps Fly from Freezing
Sandhya Sekar | Apr 30, 2014
Researchers report the first evidence of cryopreservation by an overwintering insect in which stores of an uncommon lipid are critical.
An Ancient Evolutionary Advantage?
An Ancient Evolutionary Advantage?
Emily Willingham | Apr 1, 2014
Shared sequences within the brain lipid-metabolism pathway between Neanderthals and modern Europeans highlight questions about how these genetic similarities arose.
Triglyceride Clock
Triglyceride Clock
Abby Olena | Feb 10, 2014
The timing of meals affects the levels of lipids in the livers of mice, according to a study.
Another Eczema Gene Identified
Another Eczema Gene Identified
Kerry Grens | Nov 6, 2013
Human variations in a gene that causes matted fur in mutant mice are tied to the skin malady.
How Autophagy Works
How Autophagy Works
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012
There are five steps of autophagosome biogenesis: induction, expansion, vesicle completion, fusion, and cargo degradation. 
The Enigmatic Membrane
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012
Despite years of research, the longstanding mystery of where the autophagosome gets its double lipid bilayers is not much clearer.
The Movement of Goods Around the Cell
The Movement of Goods Around the Cell
Patricia Bassereau and Bruno Goud | Apr 1, 2011
A biologist and a physicist collaborate on a decade-long exploration of the physical parameters of membrane traffic in eukaryotic cells.
Optical Tweezers
Optical Tweezers
Patricia Bassereau and Bruno Goud | Apr 1, 2011
Institut Curie researchers Bruno Goud, a biologist, and Patricia Bassereau, a physicist, talk about their fruitful, decade-long collaboration exploring the physics of membrane trafficking in a Skype interview conducted by Associate Editor Richard P. Grant.