Is It Time to Rethink Parkinson’s Pathology?
Is It Time to Rethink Parkinson’s Pathology?
New evidence points to a waste-clearing problem in patients’ cells, rather than the accumulation of protein tangles, as the root cause of the neurodegenerative disease.
Is It Time to Rethink Parkinson’s Pathology?
Is It Time to Rethink Parkinson’s Pathology?

New evidence points to a waste-clearing problem in patients’ cells, rather than the accumulation of protein tangles, as the root cause of the neurodegenerative disease.

New evidence points to a waste-clearing problem in patients’ cells, rather than the accumulation of protein tangles, as the root cause of the neurodegenerative disease.

lysosomes
Infographic: Is Cellular Waste at the Root of Parkinson’s Disease?
Infographic: Is Cellular Waste at the Root of Parkinson’s Disease?
Ashley Yeager | Oct 1, 2019
Damage to the lysosome, the organelle that removes excess proteins, lipids, and other materials, might be at the root of the disease.
Image of the Day: Lysosomes Go Traveling
Image of the Day: Lysosomes Go Traveling
The Scientist Staff | Aug 8, 2017
To chew up waste in far-reaching dendritic spines, lysosomes are trafficked sometimes hundreds of microns away from the cell bodies of neurons in rats. 
Ebola’s Cellular Key
Ebola’s Cellular Key
Amanda B. Keener | May 27, 2015
Scientists studying the basic molecular steps of Ebola infection identify a mammalian protein that is essential for the pathogen to infect mice.
Waste-Management Consultant
Waste-Management Consultant
Megan Scudellari | Nov 1, 2013
By audaciously pursuing an abandoned area of research, Ana María Cuervo discovered how cells selectively break down their waste, and revealed the health consequences when that process malfunctions.
Discoverer of Lysosomes Dies
Discoverer of Lysosomes Dies
Kate Yandell | May 8, 2013
Christian de Duve chose to be euthanized at home in Belgium at age 95.
A Malignant Alliance
Megan Scudellari | Apr 1, 2012
Two proteins interact to save adhesion molecules from degradation, potentially contributing to a more aggressive cancer.
The Enigmatic Membrane
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012
Despite years of research, the longstanding mystery of where the autophagosome gets its double lipid bilayers is not much clearer.