Mice that Survive Infection Pass on Stronger Immunity
Mice that Survive Infection Pass on Stronger Immunity
Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.
Mice that Survive Infection Pass on Stronger Immunity
Mice that Survive Infection Pass on Stronger Immunity

Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.

Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.

mice
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Sophie Fessl | Sep 10, 2021
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
Tumors Disrupt the Blood-Brain Barrier at a Distance
Tumors Disrupt the Blood-Brain Barrier at a Distance
Abby Olena | Sep 9, 2021
Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Gut Microbes Help Coordinate Immune Activity in Mice
Gut Microbes Help Coordinate Immune Activity in Mice
Catherine Offord | Jul 29, 2021
The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.
Australian Research Faces Impending Scarcity of Lab Rodents
Australian Research Faces Impending Scarcity of Lab Rodents
Bianca Nogrady | Jul 20, 2021
The Australian biomedical research community is stunned by the announced wind-down of the country’s biggest supplier of mice and rats.
Mice Plague Eastern Australia in Record Numbers
Mice Plague Eastern Australia in Record Numbers
Bianca Nogrady | Jul 12, 2021
A population explosion that began late last year has yet to abate. Meanwhile, researchers are exploring novel approaches to combat the nonnative species.
Microscopic Robots Deliver Drugs to the Brain
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
Lab-Grown Mouse Embryos Form Limbs and Organs
Lab-Grown Mouse Embryos Form Limbs and Organs
Lisa Winter | Mar 19, 2021
The embryos completed one-third of their total gestation outside of a uterus.
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
A Simple Genetic Change Adds Limb-Like Bones to Zebrafish Fins
A Simple Genetic Change Adds Limb-Like Bones to Zebrafish Fins
Abby Olena | Feb 5, 2021
A gain-of-function mutation in a single gene reveals ancient limb-forming capacity that has been preserved for hundreds of millions of years.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Astrocytes, Not Just Neurons, Play a Role in Sleep
Astrocytes, Not Just Neurons, Play a Role in Sleep
Abby Olena | Sep 24, 2020
In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.
Deep Brain Optogenetic Control Without Implants
Deep Brain Optogenetic Control Without Implants
Ruth Williams | Apr 30, 2020
Engineering an ultra-sensitive light-activated ion channel into brain cells allows for the control of neurons in live animals without a brain-implanted light source.
Infographic: Exercise’s Anticancer Mechanisms
Infographic: Exercise’s Anticancer Mechanisms
Bente Klarlund Pedersen | Apr 1, 2020
A look at the molecular processes that may feed into the tumor-fighting effects of physical activity
Infographic: CRISPR’d Cancer
Infographic: CRISPR’d Cancer
Rachael Moeller Gorman | Apr 1, 2020
Researchers use a new way to deliver CRISPR/Cas9 to tumors in mice, wiping out the cancer.
Artificial Intelligence Discovers Potent Antibiotic
Artificial Intelligence Discovers Potent Antibiotic
Amy Schleunes | Feb 22, 2020
Researchers used a machine-learning platform to test more than 100 million molecules for antibacterial activity.
Former Jackson Lab Director Ken Paigen Dies
Former Jackson Lab Director Ken Paigen Dies
Shawna Williams | Feb 20, 2020
The geneticist’s long career included leading the laboratory’s recovery from a devastating 1989 fire.
Image of the Day: Synchronized Neurons
Image of the Day: Synchronized Neurons
Amy Schleunes | Feb 14, 2020
Memory formation in mice involves coordinated activity at the cellular level that likely leads to new circuits in the brain.
Snake Venom Gland Organoids Produce Functional Toxins
Snake Venom Gland Organoids Produce Functional Toxins
Amy Schleunes | Jan 24, 2020
Stem cells from nine snake species respond to tissue culturing techniques previously used only on mouse and human stem cells.