Bispecific Antibodies Treat Cancer in Mouse Models
Bispecific Antibodies Treat Cancer in Mouse Models
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
Bispecific Antibodies Treat Cancer in Mouse Models
Bispecific Antibodies Treat Cancer in Mouse Models

A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.

A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.

p53
p53 as an Immune System Modulator in Cancer
p53 as an Immune System Modulator in Cancer
The Scientist Creative Services Team | Sep 25, 2020
Best known as a cell cycle regulator, p53 signaling mediates pro and anti-cancer immune responses as well
Elephants Revived a “Zombie” Gene that May Fend Off Cancer
Elephants Revived a “Zombie” Gene that May Fend Off Cancer
Kerry Grens | Aug 15, 2018
DNA damage kick-starts what was once a defunct duplicated gene, which kills off injured cells.
CRISPR Efficiency Tied to Cancer-Causing Process
CRISPR Efficiency Tied to Cancer-Causing Process
Kerry Grens | Jun 11, 2018
Two studies find the genome-editing technique works best when cells have a faulty DNA-damage response that’s frequently present in cancers.  
Cell Lines Gain Cancer-Related Mutations
Cell Lines Gain Cancer-Related Mutations
Kerry Grens | Apr 27, 2017
A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.
Explaining Elephants’ Cancer Resistance
Explaining Elephants’ Cancer Resistance
Jef Akst | Oct 13, 2015
Two studies reveal that the giant mammals have dozens of extra copies of a cancer-preventing gene.
Setbacks and Great Leaps
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Book Excerpt from <em>p53</em>
Book Excerpt from p53
Sue Armstrong | Mar 31, 2015
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.
An Obesity-Cancer Link?
Edyta Zielinska | Nov 22, 2011
Why obese individual are more likely to get cancer could be partly explained by a gene that activates both pathways.
MicroRNAs Prevent Cell Reprogramming
Cristina Luiggi | Oct 24, 2011
A group of microRNAs can inhibit the formation of induced pluripotent stem cells, and may provide a target for more efficient reprogramming of somatic cells.