multiple generations of family members eating at outdoor table
Sun Exposure Triggers Hunger in Men but Not Women, Study Suggests
Ultraviolet radiation leads to secretion of an appetite-boosting hormone in male mice, but experts say it’s not yet clear whether the mechanism applies to humans.
Sun Exposure Triggers Hunger in Men but Not Women, Study Suggests
Sun Exposure Triggers Hunger in Men but Not Women, Study Suggests

Ultraviolet radiation leads to secretion of an appetite-boosting hormone in male mice, but experts say it’s not yet clear whether the mechanism applies to humans.

Ultraviolet radiation leads to secretion of an appetite-boosting hormone in male mice, but experts say it’s not yet clear whether the mechanism applies to humans.

p53
Illustration of two weaving proteins 
Fusion with Spider Silk Increases Anticancer Protein’s Stability
Dan Robitzski | Jul 5, 2022
Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.
visualization of p53 protein interacting with its inhibitors MDM2 and MDMX
p53 Unleashes Endogenous Retroviruses to Tackle Tumors: Study
Marcus A. Banks | Jul 29, 2021
New experiments suggest the famous tumor-suppressing protein uses viral elements lingering in the genome to get cancerous cells to announce their presence to the immune system.
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena | Mar 5, 2021
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
p53 as an Immune System Modulator in Cancer
The Scientist Creative Services Team | Sep 25, 2020
Best known as a cell cycle regulator, p53 signaling mediates pro and anti-cancer immune responses as well
Elephants Revived a “Zombie” Gene that May Fend Off Cancer
Kerry Grens | Aug 15, 2018
DNA damage kick-starts what was once a defunct duplicated gene, which kills off injured cells.
CRISPR Efficiency Tied to Cancer-Causing Process
Kerry Grens | Jun 11, 2018
Two studies find the genome-editing technique works best when cells have a faulty DNA-damage response that’s frequently present in cancers.  
Cell Lines Gain Cancer-Related Mutations
Kerry Grens | Apr 27, 2017
A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.
Explaining Elephants’ Cancer Resistance
Jef Akst | Oct 13, 2015
Two studies reveal that the giant mammals have dozens of extra copies of a cancer-preventing gene.
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Book Excerpt from p53
Sue Armstrong | Mar 31, 2015
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.
An Obesity-Cancer Link?
Edyta Zielinska | Nov 22, 2011
Why obese individual are more likely to get cancer could be partly explained by a gene that activates both pathways.
MicroRNAs Prevent Cell Reprogramming
Cristina Luiggi | Oct 24, 2011
A group of microRNAs can inhibit the formation of induced pluripotent stem cells, and may provide a target for more efficient reprogramming of somatic cells.
The Axis of Aging
Hannah Waters | Jun 14, 2011
Editor's choice in developmental biology
Top 7 in molecular biology
Megan Scudellari | Jun 14, 2011
A snapshot of the most highly ranked articles in molecular biology, from Faculty of 1000.
Taking Aim at p53: Researchers are targeting the tumor suppressor with vectors, viruses, and small molecules
Paul Smaglik | Jan 17, 1999
p53 has emerged as one of the top targets in the war against cancer.