ISTOCK, PEKIC
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs

Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.

Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.

preclinical
Shoddy Preclinical Data Used in Clinical Trial Proposals
Shoddy Preclinical Data Used in Clinical Trial Proposals
Kerry Grens | Apr 5, 2018
Applications for Phase 1 and 2 human studies in Germany frequently lack sufficient information about an intervention’s efficacy in animal experiments, according to a new study.  
Want to Boost Reproducibility? Get Another Lab Involved
Want to Boost Reproducibility? Get Another Lab Involved
Jim Daley | Feb 22, 2018
Including as few as two labs in a study improved the odds of getting the true effect size by as much as 23 percentage points, according to a replication model.
Investigation Questions Transparency for Failed TB Vax
Investigation Questions Transparency for Failed TB Vax
Jef Akst | Jan 11, 2018
The BMJ inquiry finds that researchers presented only select results from animal experiments when applying for funding and approval for human trials.
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
Catherine Offord | Oct 3, 2017
Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.
Parkinson’s Disease Cell Therapy Relieves Symptoms in Monkeys
Parkinson’s Disease Cell Therapy Relieves Symptoms in Monkeys
Abby Olena | Aug 30, 2017
Neurons derived from human induced pluripotent stem cells fill in for lost dopamine neurons in a primate model of the disease.
Preclinical Cancer Studies Not as Reproducible as Thought
Preclinical Cancer Studies Not as Reproducible as Thought
Jef Akst | Jun 30, 2017
Researchers overestimate the reliability of findings from animal studies that are part of the Reproducibility Project: Cancer Biology.
Preclinical Studies Don't Regularly Adhere to Best Practices
Preclinical Studies Don't Regularly Adhere to Best Practices
Kerry Grens | May 8, 2017
Animal experiments published in a handful of cardiovascular journals mostly ignore NIH guidelines.
New Gene Therapy Shrinks Aggressive Tumors in Mice
New Gene Therapy Shrinks Aggressive Tumors in Mice
Aggie Mika | May 2, 2017
Scientists shut down cancer-causing fusion genes with CRISPR.
Evaluating Epigenome-Targeting Cancer Therapies
Evaluating Epigenome-Targeting Cancer Therapies
Jef Akst | Apr 3, 2017
At the annual American Association for Cancer Research meeting, researchers discuss the importance of understanding the epigenetic contributors to cancer progression and treatment response.