New Mouse Model Predicts Two Clinical Trial Failures in Humans
New Mouse Model Predicts Two Clinical Trial Failures in Humans
The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.
New Mouse Model Predicts Two Clinical Trial Failures in Humans
New Mouse Model Predicts Two Clinical Trial Failures in Humans

The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.

The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.

preclinical
Forced-Swim Test Criticized as Uninformative, Cruel
Forced-Swim Test Criticized as Uninformative, Cruel
Catherine Offord | Jul 22, 2019
Some researchers and animal rights groups are amplifying their opposition to an assay that measures how long a rodent tries to stay afloat.
Stem Cell Funding Agency CIRM Is Nearly Out of Funds
Stem Cell Funding Agency CIRM Is Nearly Out of Funds
Chia-Yi Hou | Jul 8, 2019
The California Institute for Regenerative Medicine has been funding research since it formed in 2004, giving out nearly $3 billion in grants to date.
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
Catherine Offord | Aug 31, 2018
Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.
Shoddy Preclinical Data Used in Clinical Trial Proposals
Shoddy Preclinical Data Used in Clinical Trial Proposals
Kerry Grens | Apr 5, 2018
Applications for Phase 1 and 2 human studies in Germany frequently lack sufficient information about an intervention’s efficacy in animal experiments, according to a new study.  
Want to Boost Reproducibility? Get Another Lab Involved
Want to Boost Reproducibility? Get Another Lab Involved
Jim Daley | Feb 22, 2018
Including as few as two labs in a study improved the odds of getting the true effect size by as much as 23 percentage points, according to a replication model.
Investigation Questions Transparency for Failed TB Vax
Investigation Questions Transparency for Failed TB Vax
Jef Akst | Jan 11, 2018
The BMJ inquiry finds that researchers presented only select results from animal experiments when applying for funding and approval for human trials.
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
Catherine Offord | Oct 3, 2017
Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.
Parkinson’s Disease Cell Therapy Relieves Symptoms in Monkeys
Parkinson’s Disease Cell Therapy Relieves Symptoms in Monkeys
Abby Olena | Aug 30, 2017
Neurons derived from human induced pluripotent stem cells fill in for lost dopamine neurons in a primate model of the disease.
Preclinical Cancer Studies Not as Reproducible as Thought
Preclinical Cancer Studies Not as Reproducible as Thought
Jef Akst | Jun 30, 2017
Researchers overestimate the reliability of findings from animal studies that are part of the Reproducibility Project: Cancer Biology.