Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.

A device that releases synthetic hormones slowly over time could one day provide a more practical alternative to daily birth control pills, say scientists.

The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.

Some researchers and animal rights groups are amplifying their opposition to an assay that measures how long a rodent tries to stay afloat.

The California Institute for Regenerative Medicine has been funding research since it formed in 2004, giving out nearly $3 billion in grants to date.

Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.

Applications for Phase 1 and 2 human studies in Germany frequently lack sufficient information about an intervention’s efficacy in animal experiments, according to a new study.  

Including as few as two labs in a study improved the odds of getting the true effect size by as much as 23 percentage points, according to a replication model.

The BMJ inquiry finds that researchers presented only select results from animal experiments when applying for funding and approval for human trials.

Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.

Neurons derived from human induced pluripotent stem cells fill in for lost dopamine neurons in a primate model of the disease.

Researchers overestimate the reliability of findings from animal studies that are part of the Reproducibility Project: Cancer Biology.

Animal experiments published in a handful of cardiovascular journals mostly ignore NIH guidelines.

Scientists shut down cancer-causing fusion genes with CRISPR.

At the annual American Association for Cancer Research meeting, researchers discuss the importance of understanding the epigenetic contributors to cancer progression and treatment response.

The results of a CRISPR-Cas9 study suggest that MELK—a protein thought to play a critical role in cancer—is not necessary for cancer cell survival.

Researchers use modified messenger RNA to produce a vaccine that protected mice and nonhuman primates from infection.

Researchers argue for the consideration of hormones and sex chromosomes in preclinical experiments.

Reproducibility edition