preclinical
Rethinking a Cancer Drug Target
Rethinking a Cancer Drug Target
Catherine Offord | Mar 26, 2017
The results of a CRISPR-Cas9 study suggest that MELK—a protein thought to play a critical role in cancer—is not necessary for cancer cell survival.
RNA Vaccine for Zika Shows Promise
RNA Vaccine for Zika Shows Promise
Amanda B. Keener | Feb 2, 2017
Researchers use modified messenger RNA to produce a vaccine that protected mice and nonhuman primates from infection.
The Trouble With Sex in Science
The Trouble With Sex in Science
Kerry Grens | Aug 9, 2016
Researchers argue for the consideration of hormones and sex chromosomes in preclinical experiments.
TS Picks: February 11, 2016
TS Picks: February 11, 2016
Tracy Vence | Feb 11, 2016
Reproducibility edition
In Situ Antibodies
In Situ Antibodies
Jyoti Madhusoodanan | Feb 2, 2016
Compared with systemic injections, localized antibody therapies may be more effective for some indications.
The Sounds of Silence
The Sounds of Silence
Jenny Rood | Sep 1, 2015
Science-based tinnitus therapeutics are finally coming into their own.
Organ-on-a-Chip Gets Big Pharma Boost
Organ-on-a-Chip Gets Big Pharma Boost
Bob Grant | Jun 18, 2015
Johnson & Johnson agrees to use Emulate’s blood-clot device in three of its preclinical drug programs.
Ebola Vaccines Protect Monkeys
Ebola Vaccines Protect Monkeys
Jef Akst | Apr 9, 2015
Two new Ebola vaccine candidates prove safe and effective against the virus in macaques, a study shows.
NIH to Close Sex Gap in Preclinical Research
NIH to Close Sex Gap in Preclinical Research
Rina Shaikh-Lesko | May 15, 2014
The funding agency will require grant applicants to address sex balance in all future cell and animal studies.
Opinion: Pairing Discovery with Regulatory Rigor
Opinion: Pairing Discovery with Regulatory Rigor
Shawna Jackman | May 13, 2014
To move cell-based therapies into the clinic, academic researchers may benefit by consulting researchers outside of academia and the biopharma industry.