Dark blue RNA strands with a light blue background.
| 5 min read
Human cells repair RNA breaks induced by a programmable CRISPR system, paving the way for temporary treatments for genetic diseases.

RNA editing

Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).

Infographic: RNA Editing Approaches

Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code

Infographic: DNA Isn’t Always Right-Handed

RNA Editing Possible with CRISPR-Cas13

CRISPR System Targets RNA in Mammalian Cells

CRISPR Corrects RNA-based Disease Defects

Cephalopod Genomes Contain Thousands of Conserved RNA Editing Sites

A New Way to ID Targets of RNA-Binding Proteins

CRISPR Can Tag RNA

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January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

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