A twisted and folded illustration of single-stranded RNA in front of a blue background.
Deficient RNA Editing Implicated in Inflammatory Disease 
Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.
Deficient RNA Editing Implicated in Inflammatory Disease 
Deficient RNA Editing Implicated in Inflammatory Disease 

Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.

Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.

RNA editing
DNA
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox | Dec 1, 2021
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).
Infographic: RNA Editing Approaches
Christie Wilcox | Dec 1, 2021
RNA editing platforms leverage the natural activity of ADAR enzymes to make key changes to messenger RNAs before they are translated into proteins.
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Rachel Brazil | Jun 1, 2020
Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.
Infographic: DNA Isn’t Always Right-Handed
Rachel Brazil | Jun 1, 2020
When the nucleic acid spirals to the left, it takes on a zig-zag shape known as Z-DNA that appears to regulate RNA editing.
RNA Editing Possible with CRISPR-Cas13
Ruth Williams | Oct 25, 2017
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
CRISPR System Targets RNA in Mammalian Cells
Anna Azvolinsky | Oct 4, 2017
Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.
CRISPR Corrects RNA-based Disease Defects
Kerry Grens | Aug 10, 2017
In human cells, researchers deploy the genome editor to snip out toxic repetitive sequences.
Cephalopod Genomes Contain Thousands of Conserved RNA Editing Sites
Abby Olena | Apr 6, 2017
Octopus, cuttlefish, and squid extensively edit messenger RNAs in an evolutionarily conserved process. 
A New Way to ID Targets of RNA-Binding Proteins
Ruth Williams | Jul 1, 2016
The catalytic domain of an RNA-editing enzyme is fused with RNA-binding proteins.
CRISPR Can Tag RNA
Kerry Grens | Mar 21, 2016
Modifications to the DNA-slicing program allow for monitoring the movement of messenger RNA.
Toying with RNA
Hayley Dunning | Jun 26, 2012
A new online game challenges users to design RNA sequences with the opportunity to have them brought to life.
How to Survive Freezing Waters
Jef Akst | Jan 9, 2012
For at least one species of octopus, all it takes is a little RNA editing.