RNA editing

RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.

RNA editing platforms leverage the natural activity of ADAR enzymes to make key changes to messenger RNAs before they are translated into proteins.

Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.

When the nucleic acid spirals to the left, it takes on a zig-zag shape known as Z-DNA that appears to regulate RNA editing.

Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.

Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.

In human cells, researchers deploy the genome editor to snip out toxic repetitive sequences.

Octopus, cuttlefish, and squid extensively edit messenger RNAs in an evolutionarily conserved process. 

The catalytic domain of an RNA-editing enzyme is fused with RNA-binding proteins.

Modifications to the DNA-slicing program allow for monitoring the movement of messenger RNA.

A new online game challenges users to design RNA sequences with the opportunity to have them brought to life.

For at least one species of octopus, all it takes is a little RNA editing.