schizophrenia

Researchers scratch the surface of schizophrenia susceptibility by uncovering DNA methylation differences in neonatal blood samples.

Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.

Scientists have pinpointed several pathways through which the immune system could disrupt neuronal functioning and thereby lead to psychotic symptoms.

Before its association with a pining for the toys or TV shows of yesteryear, nostalgia was deemed a dangerous psychiatric disorder.

The largest study of its kind identifies single nucleotide polymorphisms with disparate effects on men’s and women’s susceptibility to conditions such as bipolar disorder and schizophrenia.

Brain banks have struggled to convince unaffected individuals to donate, hampering studies on “cognitively normal” neurodevelopment and aging.

The gut microbiome has been linked to depression, schizophrenia, and other neurological conditions, but it’s not yet clear whether the relationship is causal.

AI models can pick up subtle alterations in linguistic and vocal attributes of spoken language that may be indicative of failing health.

A neurologist by training, Stefánsson founded Iceland-based deCODE Genetics to explore what the human genome can tell us about disease and our species’ evolution.

The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.

Complications during pregnancy may act via the placenta to magnify the effects of genetic risk factors.

The neuronal coverings that mediate synaptic changes are involved in everything from memory to psychiatric disorders, affecting autism, Alzheimer’s, and addiction.

See the web of proteins that make up these neuronal wrappings.

Transcriptional profiling of post-mortem human brains reveals commonalities in the genes over- and under-expressed in schizophrenia, bipolar disorder, autism, and major depression. 

Scientists are beginning to unravel the mechanisms behind the therapeutic effects of psychedelic drugs.

Mice lacking the RNA had deregulated microRNAs in the brain, disrupted synaptic communication, and behavioral abnormalities associated with neuropsychiatric disorders.

Genetic variants on chromosome 26 appears to play a role in a dog’s tendency to turn to people for help.