Brain cells with electrical firing. 3D rendering.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
ABOVE: © ISTOCK.COM, BESTDESIGNS
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

ABOVE: © ISTOCK.COM, BESTDESIGNS
small molecule drugs
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
Drug Helps Plants Resist Drought: Study
Abby Olena | Oct 24, 2019
The small molecule is effective in tomato and wheat in laboratory trials, but its scalability and applicability to real-world agriculture remains to be seen.
Understanding Immune-Mediated Damage After Respiratory Infection
The Scientist Creative Services Team in collaboration with 10x Genomics | Feb 17, 2021
Paul Thomas from St. Jude Children’s Research Hospital will discuss how he used single cell and spatial transcriptomics to discover the underlying mechanism of an inflammatory immune response in the lungs.
Antibiotic Assistants
Ruth Williams | Mar 9, 2016
Scientists discover compounds that restore antibiotic efficacy against drug-resistant superbugs.  
Broccoli Molecule May Ease Autism Symptoms
Molly Sharlach | Oct 14, 2014
A small study found improvements in behavior and communication skills among young men treated with sulforaphane.
High Content Phenotypic Screening and Analysis Enhances Drug Discovery
The Scientist Creative Services Team | Oct 7, 2020
Molly Shoichet and Bridget Wagner discuss strategies for using phenotypic screening to identify novel agents against diseases such as cancer and diabetes.
Some Assembly Required
Tracy Vence | Sep 3, 2013
Researchers construct nanoscale DNA cages that could eventually be used to deliver drugs to target tissues.
Cancer Growth Curtailed
Ruth Williams | Apr 4, 2013
Researchers develop two small molecules that slow the growth of human cancer cells.
The Scientist Speaks Podcast - Episode 9
The Scientist Creative Services Team | Sep 29, 2020
Repurposing Living Systems to Fight a Pandemic
Size Matters to Industry
Edyta Zielinska | Apr 11, 2012
Large molecules are more likely to make it to market these days than small molecules, according to new reports.