A validated unwinding assay with a fluorescently labeled RNA substrate helps scientists characterize helicase inhibitors via high-throughput screening.
The National Institute of Allergy and Infectious Diseases (NIAID) recently awarded BellBrook Labs a $1.8 million Phase II Small Business Innovative Research (SBIR) grant to develop small molecule antagonists of cyclic GAMP synthase (cGAS). The grant will enable BellBrook to optimize their cGAS lead molecules and test their efficacy for treating lupus-related UV light sensitivity in collaboration with Dr. Keith Elkon at the University of Washington, Seattle.
The National Cancer Institute (NCI) recently awarded BellBrook Labs a $300,000 Phase I Small Business Innovative Research (SBIR) grant to develop tools for discovering small-molecule antagonists of TREX1, a checkpoint at the top of the critical immunostimulatory STING pathway.
The new Transcreener CD73 Assay measures adenosine production by CD73 in a mix-and-read format with a far-red fluorescence polarization readout. The assay will accelerate efforts to discover selective CD73 antagonists for cancer immunotherapy by enabling high throughput screening, structure-driven hit-to-lead, and mechanistic studies with the purified enzyme.
The National Institute Of Allergy And Infectious Disease recently awarded BellBrook Labs a $300,000 Small Business Innovative Research (SBIR) grant to develop novel inhibitors for the target cyclic GAMP Synthase (cGAS). The grant will be used to accelerate the discovery of new treatments for autoimmune diseases by targeting the cGAS-STING pathway.
The newTranscreenercGAMPcGASAssay directly measures the productcGAMP, in acGASenzymatic reaction allowing researchers to screen vast compound libraries for modulators of the enzyme. The assay will be used to discover and develop new treatments for autoimmune diseases and cancer by strategically targeting thecGAS-STING pathway.
Methyltransferases have become a major focus of drug discovery for cancer and other diseases driven by epigenetic factors. BellBrook Labs’ new, ultra-sensitive AptaFluor™ SAH Methyltransferase Assay eliminates cost and sensitivity barriers that are slowing the discovery of methyltransferase inhibitors.
Discover how tissue-resident memory T cells develop within the respiratory tract and how these findings are advancing respiratory virus immunity, vaccine research, and high-throughput immune profiling.
Explore emerging mechanisms of immune checkpoint inhibitor resistance in hepatocellular carcinoma (HCC) and how combination immunotherapy strategies may improve antitumor immune responses and patient-specific treatment approaches.
Learn practical strategies for optimizing sample preparation, fragmentation, library construction, and quality control to generate high-quality next-generation sequencing (NGS) data across a range of sample types.
Learn how bulk T-cell receptor (TCR) repertoire sequencing can reveal clonotype diversity, support immune monitoring, and generate biological insights for translational immunology and biomarker discovery.
Sino Biological’s trial program enables qualified customers to evaluate SuperNuclease Pro in their specific bioprocessing applications, facilitating faster technology assessment and informed decision-making during process development
Resipher measures cellular respiration (OCR) continuously in standard 96-well plates inside your incubator, for days to weeks. No media swaps, dyes, or transfers. A live-cell functional readout for drug safety, metabolism, and mitochondrial health.
The Stirling Ultracold VAULT100™ PRO redefines ultra-low temperature storage with reliable -100°C performance, faster recovery, lower operating costs and sustainable operation. Learn how you can protect critical samples without compromise.
